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2006 Infiniti M45 Overview, Reviews, Ratings & Specs

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Cathleen V | September 29, 2025
The 2006 Infiniti M45 marked the debut of the second-generation M-series, positioning itself as a compelling full-size luxury sport sedan. Available in M45 and M45 Sport trims, it was initially priced in the low to mid-$50,000s. This model stood out with its potent V8 engine, offering robust performance, sophisticated styling, and a richly appointed interior, making it popular among buyers seeking a dynamic yet comfortable executive experience.
The Good

The 2006 Infiniti M45 boasts a powerful V8 engine for exhilarating performance, appealing to emotional drivers. Practical buyers benefit from its generally strong reliability and luxurious, comfortable interior. Its distinctive design and comprehensive features offer excellent value in the used market, blending executive prestige with a genuinely engaging driving experience for a compelling overall package.

The Bad

Known weaknesses for the 2006 Infiniti M45 include its relatively poor fuel economy due to the V8 engine. Buyers should also watch for potential suspension component wear, particularly bushings, and some reports of rust on undercarriage parts in salt-heavy regions. The infotainment system, while advanced for its time, can feel dated by modern standards.

2006 Infiniti M45: Quick Overview

Here's a bullet-point summary of the 2006 Infiniti M45's key specifications:

  • Engine: 4.5-liter DOHC 32-valve V8 (VK45DE)
  • Horsepower: 335 hp @ 6400 rpm
  • Torque: 340 lb-ft @ 4000 rpm
  • Transmission: 5-speed automatic with manual shift mode and Downshift Rev Matching
  • Fuel Economy (EPA estimated): 15 MPG city / 20 MPG highway / 17 MPG combined
  • 0-60 MPH: Approximately 5.7 to 6.0 seconds (manufacturer and independent tests vary)
  • Towing Capacity: Not officially rated or recommended for significant towing; primarily designed as a passenger luxury sedan.
  • Trim-Level Features:
    • M45 (Base):
      • Standard leather upholstery, heated 10-way power-adjustable front seats
      • Dual-zone automatic climate control with microfiltration
      • Bose premium audio system with 6-disc in-dash CD changer, 8 speakers
      • Infiniti Intelligent Key with push-button ignition
      • Bluetooth hands-free phone system
      • Power tilt and telescopic steering column
      • Bi-Xenon (HID) headlights, front fog lights
      • 18-inch aluminum-alloy wheels
      • Vehicle Dynamic Control (VDC) and Traction Control System (TCS)
      • Available with optional Navigation system, Lane Departure Warning (LDW), Intelligent Cruise Control (ICC), and climate-controlled front seats.
    • M45 Sport:
      • Includes all M45 features, plus:
      • Sport-tuned suspension for enhanced handling dynamics
      • 19-inch aluminum-alloy wheels with performance tires
      • Rear Active Steer (RAS) system for improved agility
      • More aggressive front fascia and unique side sills
      • Aluminum interior trim instead of wood accents

2006 Infiniti M45 Specifications

Vehicle Information
Year 2006
Make Infiniti
Model M45
Trim -
Style -
Type Sedan
Category Large Car
Manufacturing Details
Made In Japan
Manufacturing City TOCHIGI
Dimensions
Doors 4-Door
Curb Weight 3995 pounds
Gross Vehicle Weight Rating -
Overall Height 59.50 inches
Overall Length 192.60 inches
Overall Width 70.80 inches
Wheelbase Length 114.20 inches
Standard Seating 5
Engine & Performance
Engine 4.5-L V-8 32V DOHC
Engine Size 4.5L
Engine Cylinders 8
Transmission 5-Speed Automatic
Transmission Type Automatic
Transmission Speeds 5-Speed
Drivetrain Rear-Wheel Drive
Additional Features
Anti-Brake System 4-Wheel ABS
Steering Type Rack & Pinion
Pricing
Manufacturer Suggested Retail Price (MSRP) $49,950
Invoice Price $45,888
Delivery Charges $650

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Analysis

What Problems Does the 2006 Infiniti M45 Have?

The 2006 Infiniti M45 generally exhibits solid long-term reliability, particularly regarding its robust V8 powertrain. However, like any vehicle of its age, certain issues are frequently reported by owners. Among the most common are failures of the camshaft and crankshaft position sensors, which can lead to rough idling, stalling, or difficulty starting. While relatively inexpensive to replace, these can be a significant nuisance.

Suspension components are another area of concern, especially the bushings and control arms, which tend to wear out over time. This can result in clunks, squeaks, or a degradation in ride quality and handling, more so in the M45 Sport with its firmer tuning. Power steering pump leaks are also known to occur, necessitating replacement or repair.

A notable aesthetic long-term issue is dashboard bubbling or cracking, particularly in vehicles exposed to significant sun and heat, a common complaint across many Infiniti models of this vintage. Air conditioning system components, such as the blower motor or compressor, can also fail with age. Some owners report minor electrical gremlins, including issues with the infotainment system or Intelligent Key functionality, though these are less widespread.

Regarding recalls, the 2006 M45 was subject to a couple of important ones. The National Highway Traffic Safety Administration (NHTSA) issued recall 07V-244 in May 2007 concerning the engine control module (ECM) requiring reprogramming to address potential stalling issues at idle. More significantly, like many vehicles from that era, the 2006 M45 was included in the expansive Takata airbag inflator recall (specifically, recall 15V-287 for the front passenger side inflator). Owners should verify that these critical recalls have been addressed by a dealership for safety.

How long will the 2006 Infiniti M45 last?

With diligent maintenance, a 2006 Infiniti M45 can reliably achieve an average mileage of 150,000 to 200,000 miles, equating to 12-15 years of solid service. The VK45DE V8 engine and 5-speed automatic transmission are renowned for their long-term durability, forming a robust powertrain foundation. Many owners report these vehicles continuing to perform well beyond these figures when properly cared for.
However, long-term ownership does highlight certain weaknesses. Rubber components like suspension bushings and engine mounts are prone to wear, requiring eventual replacement. Electronic sensors, such as camshaft and crankshaft position sensors, can fail with age. Interior trim, particularly the dashboard, may show bubbling or cracking due to sun exposure over time. Rust on undercarriage components can also become an issue in regions with harsh winters, underscoring the importance of regular inspections and proactive maintenance to extend the vehicle's lifespan.

What Technology & Safety Features are Included?

The 2006 Infiniti M45 was remarkably well-equipped for its era, boasting an impressive array of built-in technology, entertainment, and advanced safety features. Standard tech included Infiniti's Intelligent Key with push-button ignition, a Bluetooth hands-free phone system, and a power tilt and telescopic steering column. Dual-zone automatic climate control with a microfilter ensured cabin comfort.

For entertainment, a premium Bose audio system with 8 speakers and a 6-disc in-dash CD changer was standard, delivering excellent sound quality. An auxiliary audio input was typically available, though sometimes in the form of RCA jacks. An optional rear-seat DVD entertainment system provided additional entertainment for passengers.

Driver-assistance features, while commonplace today, were pioneering for 2006. The M45 offered an optional Lane Departure Warning (LDW) system, notably one of the first production vehicles in the US to feature this technology. Also available was Intelligent Cruise Control (ICC), Infiniti's adaptive cruise control system, and a RearView Monitor (backup camera) integrated with the optional navigation system.

Safety was a strong point, with comprehensive features including standard Anti-lock Braking System (ABS), Electronic Brake force Distribution (EBD), Brake Assist (BA), Vehicle Dynamic Control (VDC), and Traction Control System (TCS). Passive safety included advanced front airbags, front seat-mounted side-impact airbags, and roof-mounted curtain side-impact airbags for both front and rear occupants. Front seat active head restraints and a Tire Pressure Monitoring System (TPMS) further enhanced safety.

Crash-test ratings from the National Highway Traffic Safety Administration (NHTSA) were excellent:

  • Frontal Driver: 5 Stars
  • Frontal Passenger: 5 Stars
  • Side Front Seat: 5 Stars
  • Side Rear Seat: 5 Stars
  • Rollover: 4 Stars

While the Insurance Institute for Highway Safety (IIHS) did not conduct as many specific tests like the small overlap frontal for vehicles of this model year, the NHTSA ratings demonstrate a strong safety performance.

What Colors Options are Available?

We’re working on this section!
In the meantime, feel free to explore the other sections for more content.

2006 Infiniti M45 Prices and Market Value

When new, the 2006 Infiniti M45 had an MSRP starting around $49,900 for the base model, with the M45 Sport trim beginning at approximately $51,900, and fully optioned versions approaching $55,000 or more.
In today's used market, prices have depreciated significantly, making it an excellent value proposition for buyers. Current used prices typically range from $3,000 to $6,000 for models in fair to good condition with average mileage, while well-maintained, lower-mileage examples might fetch between $6,000 and $9,000, and exceptionally pristine cars occasionally command slightly higher figures.
Depreciation for luxury sedans like the M45 is steep, especially for V8 models, meaning the vast majority of its value loss has already occurred. Factors heavily affecting current resale value include overall mechanical and cosmetic condition, complete service records, mileage, and the presence of desirable options like the navigation system. Regional demand and the vehicle's rust-free status also play a crucial role in its perceived value.

2006 Infiniti M45 Cost of Ownership

Owning a 2006 Infiniti M45 comes with a moderately high cost of ownership, largely influenced by its luxury V8 nature. Insurance premiums tend to be above average compared to mainstream sedans, reflecting its performance and luxury status. Fuel costs are significant; the 4.5L V8 requires premium unleaded fuel and achieves modest economy (around 15 city/20 highway MPG).
Maintenance, while manageable with a good independent mechanic, can be more expensive than average due to specialized fluids and parts for a luxury vehicle. Common repairs like suspension component replacements or sensor failures can incur substantial costs. Long-term ownership demands attention to potential issues like dashboard cracking and rust prevention in certain climates. Overall, while the initial purchase price is low, budgeting for higher fuel, maintenance, and potential repair costs is essential; it is not an economical vehicle to own compared to a compact or mid-size sedan.

2006 Infiniti M45 Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 20.00 gallons
City Mileage 17 miles/gallon
Highway Mileage 23 miles/gallon

2006 Infiniti M45 Safety Rating

NHTSA
Side Driver Rating
Frontal Passenger Rating
Rollover Rating
Side Rear Passenger Rating
Frontal Driver Rating
IIHS
Rear Crash Protection/Head Restraint Ratings Not Tested
Moderate Overlap Front Test Results Good
Side Impact Test Results Good

2006 Infiniti M45 Warranty

Basic
Original warranty 48 months / 60,000 miles
Estimated remaining Expired
Powertrain
Original warranty 72 months / 70,000 miles
Estimated remaining Expired
Rust
Original warranty 84 months / unlimited miles
Estimated remaining Expired

2006 Infiniti M45 Insurance

Insurance for a 2006 Infiniti M45 is moderately priced, reflecting its status as a Sedan with strong safety ratings and
reasonable repair costs.

How Does the 2006 Infiniti M45 Compare to Other Sedan?

The 2006 Infiniti M45 competes squarely in the full-size luxury sport sedan segment, stacking up against formidable rivals like the Lexus GS 430, BMW 5 Series (E60, such as the 545i or 550i), Mercedes-Benz E-Class (W211 E500/E550), and the Audi A6 4.2 quattro.

  • Performance: The M45's 335-hp V8 provides strong, linear acceleration, often matching or exceeding the performance of base V8 European rivals. While a BMW 5 Series might offer a slightly sharper, more engaging driving dynamic for enthusiasts, the M45 Sport's sport-tuned suspension and Rear Active Steer (RAS) system make it surprisingly agile. The Lexus GS 430, while powerful, tends to be more comfort-oriented and less overtly sporty.
  • Features: Infiniti equipped the M45 generously, often offering more standard amenities than its European counterparts at a similar price point. Pioneering features like optional Lane Departure Warning and Intelligent Cruise Control were significant differentiators. Its Bose audio system and comfortable interior rivaled anything in its class.
  • Reliability: Generally, the M45 holds a good reputation for reliability, often considered more robust than its contemporary BMW or Mercedes-Benz rivals, especially concerning long-term electrical and drivetrain issues. While not quite reaching the bulletproof status of a Lexus GS, it strikes a strong balance between performance and dependability.
  • Price (Used Market): This is where the M45 truly shines. Its significant depreciation makes it a phenomenal used value compared to any of its rivals. You can often acquire a well-maintained M45 for considerably less than a comparable Lexus GS, and dramatically less than a BMW 5 Series or Mercedes E-Class, despite offering similar luxury and performance.

Recommended Alternatives:

  • For similar V8 luxury and potentially better long-term reliability: A used Lexus GS 430 or GS 470 (if SUV) would be a strong, albeit often pricier, alternative.
  • For more engaging driving dynamics (with higher maintenance risk): A BMW 545i or 550i.
  • For excellent value in a luxury sedan (without the V8): The Acura RL, which offers standard AWD and great reliability, or even a V6 Infiniti M35 of the same generation.
  • For sheer luxury at a low used price (be prepared for high maintenance): A Mercedes-Benz E500.

Final Verdict: Is the 2006 Infiniti M45 a Good Sedan?

The 2006 Infiniti M45 is an ideal vehicle for discerning buyers seeking a powerful, luxurious, and well-equipped full-size sedan on a budget. It's perfect for someone who appreciates the effortless thrust of a V8 engine, a comfortable and feature-rich cabin, and a driving experience that balances sporty ambition with executive refinement.
Given its significant depreciation, the M45 is absolutely worth buying exclusively as a used vehicle. However, it comes with conditions: a thorough pre-purchase inspection (PPI) by a trusted mechanic is essential to identify potential issues, especially regarding suspension and electronics. Buyers should also be prepared for above-average running costs, particularly for premium fuel and potentially more expensive maintenance and repair parts compared to a mainstream car.
Either the standard M45 or the M45 Sport trim offers a compelling package, with the Sport providing a firmer ride and enhanced handling for those prioritizing dynamism. Find a well-maintained example with documented service history, and the 2006 M45 delivers exceptional luxury and performance value.

2006 Infiniti M45 Owner Reviews

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Cathleen V

Cathleen is an exceptional freelance writer covering hot topics in the automotive world from a gearhead's perspective. Her articles delve into various aspects of automotive technology and history, offering readers detailed insights into engine performance, reliability, and maintenance. Through her engaging and informative writing, Cathleen provides valuable information to automotive enthusiasts and consumers alike, helping them make informed decisions about vehicle maintenance and purchases.