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2021 Lexus RX 350L Overview, Reviews, Ratings & Specs

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Simon A | September 27, 2025
The 2021 Lexus RX 350L is a sophisticated three-row mid-size luxury SUV, part of the fourth-generation RX lineup (2016-present), with the "L" extended variant introduced in 2018. It offers an elongated body for additional passenger and cargo capacity. Key trims include the RX 350L (base), Premium, and Luxury. New, it typically ranged from around $48,000 to $58,000. It stands out for its legendary Lexus reliability, serene cabin, smooth ride, and distinctive styling, making it a popular choice for families seeking comfort and luxury.
The Good

The 2021 Lexus RX 350L excels with its renowned reliability, a smooth and quiet V6 performance, and an exceptionally comfortable, well-appointed cabin. Its distinctive, elegant design appeals emotionally, while practical buyers appreciate its strong resale value, decent fuel efficiency for its class, and comprehensive safety features. It's a luxurious sanctuary on wheels, offering peace of mind and prestige.

The Bad

Despite its "L" designation, the 2021 Lexus RX 350L's third row remains cramped for adults, primarily suitable for children. The Remote Touch infotainment interface can be unintuitive and distracting to operate while driving. Its comfort-oriented suspension means it lacks the sporty driving dynamics found in some rivals, and cargo space with the third row in use is limited.

2021 Lexus RX 350L: Quick Overview

  • Engine Options: The 2021 Lexus RX 350L is exclusively powered by a 3.5-liter V6 engine.

  • Horsepower: This V6 engine produces a robust 290 horsepower and 263 lb-ft of torque. It is paired with an 8-speed automatic transmission.

  • Fuel Economy:
    • FWD: EPA-estimated 19 mpg city / 26 mpg highway / 22 mpg combined.
    • AWD: EPA-estimated 18 mpg city / 25 mpg highway / 21 mpg combined.

  • 0-60 Times: The RX 350L FWD typically accelerates from 0-60 mph in approximately 7.9 seconds, while the AWD version is slightly quicker at around 7.8 seconds.

  • Towing Capacity: When properly equipped, the 2021 Lexus RX 350L has a maximum towing capacity of 3,500 pounds.

  • Trim-Level Features:
    • RX 350L (Base): Standard features include 18-inch wheels, LED headlights, a power liftgate, tri-zone automatic climate control, synthetic leather upholstery (NuLuxe), an 8-inch infotainment display with Apple CarPlay and Android Auto, a nine-speaker sound system, and the full Lexus Safety System+ 2.0 suite. It also comes with a power-folding third-row seat.

    • RX 350L Premium: Builds upon the base trim by adding a power moonroof, roof rails, driver's seat memory functions, and an auto-dimming power-folding outside mirror. Optional features become available, such as heated and ventilated front seats, wood trim, and a navigation system.

    • RX 350L Luxury: The top-tier trim includes all Premium features plus 20-inch wheels with a unique design, semi-aniline leather upholstery, heated and ventilated front seats, a heated steering wheel, ambient interior lighting, rear door sunshades, and a 12-speaker audio system. Additional options like a 12.3-inch infotainment display, a head-up display, and a Mark Levinson sound system are often found on this trim.

2021 Lexus RX 350L Specifications

Vehicle Information
Year 2021
Make Lexus
Model RX 350L
Trim -
Style -
Type Sport Utility Vehicle
Category Standard Sport Utility Vehicle
Manufacturing Details
Made In Japan
Manufacturing City MIYAWAKA
Dimensions
Doors 4-Door
Curb Weight -
Gross Vehicle Weight Rating 2721.55 kg
Overall Height 170.94 cm
Overall Length 500.13 cm
Overall Width 189.48 cm
Wheelbase Length 278.89 cm
Standard Seating 7
Engine & Performance
Engine 3.5-L V-6 DOHC 24V
Engine Size 3.5L
Engine Cylinders 6
Transmission 6-Speed Automatic
Transmission Type Automatic
Transmission Speeds 6-Speed
Drivetrain Front-Wheel Drive
Additional Features
Anti-Brake System 4-Wheel ABS
Steering Type Rack & Pinion
Pricing
Manufacturer Suggested Retail Price (MSRP) $48,925 USD
Invoice Price $45,812 USD
Delivery Charges $1,025 USD

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What Problems Does the 2021 Lexus RX 350L Have?

The 2021 Lexus RX 350L, in line with Lexus's reputation for exceptional reliability, has generally few widespread or serious frequently reported problems. Owners consistently praise its robust engineering and durable components. However, minor inconveniences or specific points of contention have been noted.

One common feedback point revolves around the infotainment system, specifically the Lexus Remote Touch controller. While not a "problem" in terms of mechanical failure, many users find it clunky, imprecise, and distracting to operate compared to touchscreens or rotary controllers offered by competitors. This can lead to frustration, particularly when trying to input navigation destinations or switch audio sources while driving. Some minor software glitches or occasional system freezes have been reported, although these are typically resolved with a simple restart.

Another area of minor concern, primarily subjective, is the braking feel. Some owners describe the brakes as being a bit soft or having a longer pedal travel than desired, which can take some getting used to. This isn't a safety issue but rather a matter of preference compared to more immediate-feeling braking systems.

Regarding recalls, the 2021 Lexus RX 350L had relatively few at the time of its release. One notable recall (NHTSA Campaign Number 20V682000) involved the possibility of the fuel pump failing, which could cause the engine to stall. This issue affected a broad range of Toyota and Lexus vehicles, including the RX, from various model years, and was addressed by dealerships replacing the fuel pump assembly. Another recall (NHTSA Campaign Number 20V772000) concerned the front passenger seat belt webbing, which might not be correctly routed, potentially affecting occupant restraint. Both of these were manufacturer-issued recalls with specific remedies.

Long-term reliability for the RX series is outstanding, and the 2021 model is expected to follow this trend. Major powertrain components like the engine and transmission are known for their durability. As vehicles age, typical wear items like suspension components, bushings, and certain electrical sensors will eventually require replacement, but these are standard maintenance considerations for any vehicle rather than specific weaknesses of the RX 350L.

How long will the 2021 Lexus RX 350L last?

The 2021 Lexus RX 350L, benefiting from Lexus's legendary build quality, is designed for exceptional longevity. With diligent maintenance, it's not uncommon for these vehicles to exceed 200,000 miles, and many owners report reaching 250,000 to 300,000 miles or more. This translates to an average of 15 to 20 years of reliable service for owners who adhere to the recommended service schedule.

Long-term durability is a major strong point. The 3.5-liter V6 engine and 8-speed automatic transmission are renowned for their robustness. While major mechanical failures are rare, common long-term wear items may include suspension components like struts and bushings, which can degrade over high mileage, affecting ride quality. Minor electrical components or infotainment glitches might also surface with age, but these are typically less severe and more manageable than issues found in some European rivals. Overall, the RX 350L is an incredibly durable vehicle, offering excellent long-term value and reliability.

What Technology & Safety Features are Included?

The 2021 Lexus RX 350L comes equipped with a comprehensive suite of technology, entertainment, and safety features, offering a luxurious and secure driving experience. Standard entertainment tech includes an 8-inch infotainment display controlled by the Lexus Remote Touchpad. This system supports Apple CarPlay, Android Auto, and Amazon Alexa integration, providing seamless smartphone connectivity. A nine-speaker audio system is standard, with an optional premium 12.3-inch display and an acclaimed 15-speaker Mark Levinson surround-sound system available on higher trims for audiophiles.

Driver-assistance features are a highlight, thanks to the standard Lexus Safety System+ 2.0. This advanced suite includes a Pre-Collision System with Pedestrian Detection, Lane Tracing Assist, Lane Departure Alert with Steering Assist, Road Sign Assist, All-Speed Dynamic Radar Cruise Control, and Intelligent High Beams. These technologies work together to enhance driver awareness and reduce the likelihood of accidents. Optional driver assistance features often include a panoramic view monitor, blind-spot monitoring with rear cross-traffic alert, and parking assist.

In terms of passive safety, the RX 350L is fitted with 10 airbags, including knee airbags for the driver and front passenger, along with vehicle stability control, traction control, and anti-lock brakes. The structure is designed to absorb impact energy effectively. Crash-test ratings for the 2021 Lexus RX 350L are impressive: The National Highway Traffic Safety Administration (NHTSA) awarded it an overall Five-Star Safety Rating. The Insurance Institute for Highway Safety (IIHS) gave the standard 2021 RX (which generally applies to the RX L due to structural similarities) top "Good" ratings in all crashworthiness tests and a "Superior" rating for front crash prevention, earning it a Top Safety Pick award when equipped with specific headlights.

What Colors Options are Available?

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2021 Lexus RX 350L Prices and Market Value

When new, the 2021 Lexus RX 350L had a Manufacturer's Suggested Retail Price (MSRP) ranging from approximately $48,000 for the base FWD model to over $58,000 for a fully equipped AWD Luxury trim. Options and packages could push these figures higher.

In the current used market (as of late 2023/early 2024), a 2021 Lexus RX 350L can typically be found ranging from $35,000 to $45,000, depending significantly on mileage, condition, trim level, and optional features. Depreciation for the Lexus RX lineup is remarkably low compared to many luxury rivals. Lexus vehicles are known for holding their value exceptionally well, making them a wise investment. Factors positively affecting resale value include low mileage, excellent maintenance history, desirable packages (like the larger infotainment screen, Mark Levinson audio, or advanced driver aids), and the presence of all-wheel drive (AWD), especially in regions with inclement weather. A clean title and accident-free history are also crucial.

2021 Lexus RX 350L Cost of Ownership

The 2021 Lexus RX 350L presents a balanced cost of ownership for a luxury SUV. Insurance costs are generally moderate to high, typical for a premium vehicle in its class, varying by driver profile and location. Fuel efficiency is respectable for a three-row V6 SUV, averaging around 21-22 mpg combined, making it reasonably economical at the pump. Maintenance costs are lower than many European luxury competitors, though still higher than mainstream brands, especially if serviced at a Lexus dealership. Repairs are infrequent due to Lexus's high reliability, but parts can be more expensive when needed. Overall, the RX 350L is considered quite economical to own in the luxury segment, largely due to its strong reliability and excellent resale value, offsetting slightly higher initial costs for insurance and premium maintenance.

2021 Lexus RX 350L Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 72.68 liters
City Mileage 8.08 km/l
Highway Mileage 11.05 km/l

2021 Lexus RX 350L Safety Rating

NHTSA
Overall Rating
Overall Frontal Star Rating
Side Overall Star Rating
Overall Rollover Star Rating
Combined Front Seat Rating
Combined Rear Seat Rating
Overall Frontal Star Rating
Frontal Barrier Star Ratings Not Tested
Overall Side Star Rating
Side Barrier Star Ratings
Side Pole Star Rating
Combined Side Barrier And Side Pole Star Ratings Not Tested
Rollover Resistance Star Rating

2021 Lexus RX 350L Warranty

Basic
Original warranty 48 months / 50,000 miles
Estimated remaining Expired
Powertrain
Original warranty 72 months / 70,000 miles
Estimated remaining 24 months / 70,000 miles
Rust
Original warranty 72 months / unlimited miles
Estimated remaining 24 months / unlimited miles

2021 Lexus RX 350L Insurance

Insurance for a 2021 Lexus RX 350L is moderately priced, reflecting its status as a Sport Utility Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2021 Lexus RX 350L Compare to Other Sport Utility Vehicle?

The 2021 Lexus RX 350L competes in a fiercely contested mid-size luxury SUV segment. Its primary rivals include the Acura MDX, Infiniti QX60, Volvo XC90, Audi Q7, and BMW X5.

In terms of performance, the RX 350L's 290-hp V6 offers smooth, adequate power for most situations, but it prioritizes comfort and refinement over outright sportiness. Rivals like the BMW X5 and Audi Q7 provide significantly more engaging driving dynamics and often more powerful engine options. The Acura MDX offers a sportier feel than the RX, while the Infiniti QX60 is more aligned with the RX's comfort-focused approach.

Regarding features, the RX 350L comes generously equipped with the standard Lexus Safety System+ 2.0, which is comprehensive. Its infotainment system, however, with the Remote Touch interface, is less intuitive than the systems found in the Q7's MMI, XC90's Sensus, or MDX's True Touchpad Interface. While Apple CarPlay and Android Auto are present, the user experience can be frustrating. The Volvo XC90 often offers more advanced semi-autonomous driving features, and the Q7 and X5 boast more technologically advanced cabins.

Where the RX 350L truly shines is reliability. Lexus consistently ranks at or near the top in dependability surveys, far surpassing most European rivals like Audi, BMW, and Volvo, and often outperforming Acura and Infiniti. This legendary reliability is a major draw for many buyers.

In terms of price, the RX 350L is competitively priced within the segment, often undercutting similarly equipped Audi Q7s or BMW X5s when new. Its exceptional resale value further enhances its long-term value proposition.

Similar Alternatives:
  • Acura MDX: Offers a more engaging driving experience, a more spacious and usable third row, and an intuitive infotainment system. It's a strong competitor if sportiness and third-row utility are higher priorities.
  • Infiniti QX60: Provides a comfortable ride, a generally intuitive infotainment system (especially in later models), and competitive pricing. It aligns well with the RX's comfort-oriented approach but might not match Lexus's long-term reliability reputation.

Better Alternatives (depending on priority):
  • Volvo XC90: If design, advanced safety features, and a more modern, spacious third row are paramount, the XC90 is a compelling choice, though its reliability history isn't quite at Lexus levels.
  • Audi Q7/BMW X5: For those prioritizing driving dynamics, sophisticated technology, and premium interior materials, these German rivals offer a more athletic and luxurious experience, albeit typically at a higher price and with potentially higher ownership costs.

Final Verdict: Is the 2021 Lexus RX 350L a Good Sport Utility Vehicle?

The 2021 Lexus RX 350L is ideal for buyers prioritizing a supremely comfortable, quiet, and reliable luxury SUV with the occasional need for a third row. It appeals to families who value safety, low long-term ownership costs, and a serene driving experience over sporty handling or cutting-edge infotainment. It's particularly suited for those who appreciate Lexus's reputation for dependability and excellent resale value.

Yes, the 2021 RX 350L is absolutely worth buying, especially as a used vehicle. Its robust depreciation curve means you can acquire a well-maintained model at a significant discount from its new price, offering tremendous value. For optimal comfort and features, consider a Premium or Luxury trim, as these add desirable amenities like heated/ventilated seats and upgraded audio. Opt for the AWD version if you live in an area with snow or require enhanced traction. While its third row is best for children, for its target demographic, the RX 350L remains a smart, luxurious, and dependable choice.

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Simon A

Simon is a contributor to VinCheck, where he provides articles and reviews on various automotive topics. His work focuses on delivering accurate and up-to-date information about used cars, helping readers make informed decisions.