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2021 Lexus RX 450h Overview, Reviews, Ratings & Specs

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Eugene S | September 25, 2025
The Lexus RX, a luxury crossover SUV, has been a popular choice for decades, known for its reliability and comfortable ride. The 2021 RX 450h continues this tradition as a hybrid variant. It's offered in several trims, including base, F Sport, and Black Line Special Edition. Pricing typically ranged from around $48,000 to $58,000 when new. Its blend of luxury, fuel efficiency, and Lexus's reputation for dependability makes it stand out.
The Good

The 2021 Lexus RX 450h excels in reliability, comfort, and fuel efficiency. Its smooth ride and luxurious interior appeal to emotional buyers, while practical buyers appreciate its hybrid powertrain, excellent safety ratings, and strong resale value. The design is modern and upscale, adding to its overall desirability and performance.

The Bad

While generally reliable, the 2021 Lexus RX 450h can suffer from infotainment system issues, particularly with the touchpad interface, which many find cumbersome. The sporty F Sport trim's ride can be firmer than some buyers prefer. Towing capacity is limited. Some may find the acceleration adequate but not thrilling compared to some competitors.

2021 Lexus RX 450h: Quick Overview

  • Engine: 3.5-liter V6 engine paired with electric motors
  • Horsepower: Total system horsepower of 308 hp
  • Fuel Economy:
    • EPA-estimated 31 mpg city / 28 mpg highway / 30 mpg combined (FWD)
    • EPA-estimated 30 mpg city / 28 mpg highway / 30 mpg combined (AWD)
  • 0-60 mph: Approximately 7.9 seconds
  • Towing Capacity: 3,500 lbs (when properly equipped)
  • Trim-Level Features:
    • Base: 8-inch touchscreen, Apple CarPlay/Android Auto, Lexus Safety System+ 2.0 (includes pre-collision system, lane departure alert, adaptive cruise control), power-adjustable front seats, dual-zone automatic climate control.
    • F Sport: Sport-tuned suspension, unique exterior styling, sport seats, aluminum pedals, performance-inspired instrumentation.
    • Black Line Special Edition: Unique black exterior accents, black wheels, blue stitching on interior elements. Features largely based on the Premium Package.
    • Optional Features/Packages (across trims): 12.3-inch touchscreen, navigation, Mark Levinson premium audio system, panoramic sunroof, blind-spot monitoring, rear cross-traffic alert, parking assist, head-up display, wireless charging, heated and ventilated front seats, leather upholstery.

2021 Lexus RX 450h Specifications

Vehicle Information
Year 2021
Make Lexus
Model RX 450h
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What Problems Does the 2021 Lexus RX 450h Have?

The 2021 Lexus RX 450h is generally considered reliable, but some owners have reported issues. A common complaint revolves around the infotainment system, specifically the touchpad interface. Users find it distracting and difficult to use while driving. Some have also experienced occasional software glitches. There have been few recalls for the 2021 model year. Long-term reliability concerns are minimal, consistent with Lexus's reputation. However, as with any hybrid, the battery pack's longevity is a consideration. While Lexus hybrid batteries often last well beyond 100,000 miles, eventual replacement is a potential expense. Some owners have reported minor issues with the hybrid system, such as warning lights or occasional rough transitions between electric and gasoline power, but these are not widespread. Regular maintenance, particularly adhering to Lexus's recommended service schedule, is crucial for ensuring long-term reliability of the hybrid components. Overall, the 2021 RX 450h maintains Lexus's strong reliability record, with fewer reported problems compared to some competitors, however potential buyers should research current TSBs (Technical Service Bulletins).

How long will the 2021 Lexus RX 450h last?

With proper maintenance, a 2021 Lexus RX 450h can easily achieve 200,000 miles or more and last for 10-15 years. Lexus vehicles are renowned for their durability. Key to longevity is following the recommended maintenance schedule, including regular oil changes, fluid checks, and inspections. The hybrid battery is a critical component; its lifespan is influenced by driving habits and climate. While designed for long-term use, eventual replacement is a factor. Weaknesses over time are typically limited to wear items like brakes, tires, and suspension components. Some interior materials may show wear and tear after many years of use.

What Technology & Safety Features are Included?

The 2021 Lexus RX 450h comes standard with an 8-inch touchscreen infotainment system with Apple CarPlay and Android Auto integration. Higher trims offer a 12.3-inch display with navigation. The infotainment system is controlled via a touchpad, which is a point of contention for many users. A Mark Levinson premium audio system is available as an option.
Driver-assistance and safety features are comprehensive, including:
  • Lexus Safety System+ 2.0: Pre-Collision System with Pedestrian Detection, Lane Departure Alert with Steering Assist, Lane Tracing Assist, Adaptive Cruise Control, Road Sign Assist.
  • Blind Spot Monitor with Rear Cross-Traffic Alert (optional)
  • Parking Assist (optional)
  • Automatic High Beams
Crash-test ratings are generally excellent. The NHTSA (National Highway Traffic Safety Administration) typically awards the RX 450h with a 5-star overall safety rating. The IIHS (Insurance Institute for Highway Safety) often gives the RX good ratings in crash tests, sometimes awarding it a Top Safety Pick.
Other optional features include a head-up display, wireless charging, and a panoramic sunroof. The RX 450h prioritizes safety and includes a robust suite of driver-assistance features as standard equipment.

What Colors Options are Available?

Exterior Colors
Atomic Silver
Caviar
Cloudburst Gray
Eminent White Pearl
Matador Red Mica
Moonbeam Beige Metallic
Nightfall Mica
Nori Green Pearl
Obsidian
Interior Colors
Black
Parchment
Black w/Open-Pore Brown Walnut Trim
Parchment w/Open-Pore Brown Walnut Trim
Birch
Birch w/Laser Etched Black Wood Trim
Black w/ Striated Black Trim
Glazed Caramel
Glazed Caramel w/Open-Pore Brown Walnut Trim
Moonstone
Moonstone w/ Open-Pore Brown Walnut Trim

2021 Lexus RX 450h Prices and Market Value

The 2021 Lexus RX 450h had a starting MSRP of around $48,000 to $58,000 depending on the trim and options. As of late 2024, used market prices typically range from $35,000 to $45,000, depending on mileage, condition, and location. Lexus vehicles generally hold their value well, resulting in moderate depreciation. Factors affecting resale value include mileage, condition, service history, and the presence of desirable options such as the larger touchscreen, Mark Levinson audio system, and advanced safety features. Lower mileage examples and well-maintained vehicles command higher prices.

2021 Lexus RX 450h Cost of Ownership

The 2021 Lexus RX 450h is generally economical to own. Insurance costs are moderate, reflecting its safety ratings and repair costs. Fuel efficiency is a major advantage thanks to its hybrid powertrain. Maintenance costs are reasonable, especially if adhering to the recommended service schedule. While Lexus parts can be more expensive, the vehicle's reliability reduces the need for frequent repairs. Overall, long-term ownership costs are lower than average for a luxury SUV due to its fuel efficiency and dependability.

2021 Lexus RX 450h Fuel Efficiency

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2021 Lexus RX 450h Safety Rating

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2021 Lexus RX 450h Insurance

Insurance for a 2021 Lexus RX 450h is moderately priced, reflecting its status as a Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2021 Lexus RX 450h Compare to Other Vehicle?

The 2021 Lexus RX 450h competes with other luxury hybrid SUVs such as the Acura MDX Hybrid, BMW X3 xDrive30e, and Volvo XC60 Recharge. In terms of reliability, the RX 450h typically outperforms its rivals. Performance is adequate but not as sporty as the BMW. Features are comparable, though some rivals offer more intuitive infotainment systems. Price-wise, the RX 450h is competitive.
Alternatives:
  • Acura MDX Hybrid: Offers more space and a sportier driving experience, but may not match the Lexus's reliability.
  • BMW X3 xDrive30e: Provides a more engaging driving experience, but reliability is not as strong, and it's more expensive.
  • Volvo XC60 Recharge: Boasts a stylish design and strong safety features, but can be less reliable and more costly to maintain.
If reliability and fuel efficiency are top priorities, the RX 450h is an excellent choice. If a more engaging driving experience is desired, the BMW or Acura might be better options, but consider potential reliability trade-offs. The Volvo offers style but may come with higher ownership costs.

Final Verdict: Is the 2021 Lexus RX 450h a Good Vehicle?

The 2021 Lexus RX 450h is an ideal choice for buyers seeking a reliable, comfortable, and fuel-efficient luxury SUV. It's particularly well-suited for those prioritizing dependability and a smooth ride over sporty handling. It's generally worth buying, especially on the used market where depreciation makes it a more attractive value proposition. Consider a used model with a comprehensive service history. The base or Premium trims offer the best value, while the F Sport trim is suitable for those wanting slightly sportier styling but bear in mind the firmer ride. Overall, the 2021 RX 450h provides a balanced and dependable ownership experience.

2021 Lexus RX 450h Owner Reviews

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Eugene S

Eugene is an automotive enthusiast with over 15 years of experience in the used car market. As a writer at VINCheck.info, he brings deep industry insight and a passion for cars, helping readers make smart, informed decisions. Eugene has written hundreds of used car reviews and is known for breaking down complex automotive topics into clear, actionable advice. Over the years, he has driven and worked on a wide range of vehicles—starting with tuning street cars in his early days and eventually focusing on performance upgrades and reliability improvements. Today, he specializes in evaluating used vehicles through the lens of real-world ownership and enthusiast needs. A longtime fan of Porsche, Eugene especially appreciates vehicles that blend durability with driving enjoyment.