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2021 Lexus RX 350 Overview, Reviews, Ratings & Specs

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Eugene S | October 4, 2025
The 2021 Lexus RX 350 is a popular mid-size luxury SUV, part of a model line that debuted in 1998. It's offered as a two-row SUV or a longer L version with a third row. Key trims for 2021 include the base RX 350, RX 350 F SPORT, and the RX 350L. With a starting MSRP around $45,000, its popularity stems from its reputation for exceptional reliability, a plush and quiet interior, and a smooth, comfortable ride. It appeals to buyers seeking a refined and dependable luxury experience.
The Good

The 2021 RX 350 excels in reliability, offering peace of mind. Its comfortable, quiet cabin and smooth ride appeal to emotional desires for luxury and relaxation. Practically, it provides decent fuel economy and a strong value proposition with its renowned durability.

The Bad

Buyers should be aware of the 2021 RX 350's somewhat uninspired powertrain, which can feel sluggish during spirited driving. The infotainment system, particularly the trackpad interface, can be frustrating to use. Cargo space in the standard model is also less than some rivals.

2021 Lexus RX 350: Quick Overview

  • Engine Options: The 2021 Lexus RX 350 comes standard with a 3.5-liter V6 engine.
  • Horsepower: This V6 engine produces 295 horsepower and 263 lb-ft of torque.
  • Transmission: It is paired with an 8-speed automatic transmission.
  • Drivetrain: Front-wheel drive (FWD) is standard, with all-wheel drive (AWD) available as an option on most trims.
  • Fuel Economy (FWD): Estimated at 20 MPG city / 27 MPG highway / 23 MPG combined.
  • Fuel Economy (AWD): Estimated at 19 MPG city / 26 MPG highway / 22 MPG combined.
  • 0-60 Times: Approximately 7.9 seconds for FWD and 8.2 seconds for AWD models.
  • Towing Capacity: The RX 350 has a maximum towing capacity of 3,500 pounds when properly equipped.
  • Trim-Level Features:
    • RX 350 (Base): Standard features include LED headlights, 18-inch alloy wheels, synthetic leather upholstery, power-adjustable front seats, a power liftgate, dual-zone automatic climate control, a 12-speaker audio system, an 8-inch touchscreen infotainment system with Apple CarPlay and Android Auto compatibility, and a suite of driver-assistance features (see prompt 7).
    • RX 350 F SPORT: Adds sport-tuned suspension, unique exterior and interior styling elements, perforated leather-trimmed steering wheel and shift knob, aluminum pedals, front and rear performance dampers, and 20-inch F SPORT wheels.
    • RX 350L: This is the extended wheelbase version, offering a third row of seating, though it compromises some cargo space in the second row. It shares most features with the base RX 350 but includes a power-folding third-row seat.
    • Optional Features: Available options across trims include a panoramic glass sunroof, navigation system, upgraded Mark Levinson audio system, heated and ventilated front seats, heated steering wheel, power-folding second-row seats, a color-keyed rear-seat entertainment system, and a hands-free power liftgate.

2021 Lexus RX 350 Specifications

Vehicle Information
Year 2021
Make Lexus
Model RX
Trim -
Style Automatic
Type Sport Utility Vehicle
Category Minicompact Car Small Sport Utility Vehicle 2WD
Manufacturing Details
Made In Canada
Manufacturing City CAMBRIDGE
Dimensions
Doors 4-Door
Curb Weight 1915.07 kg
Gross Vehicle Weight Rating 2721.55 kg
Overall Height 171.96 cm
Overall Length 488.95 cm
Overall Width 189.48 cm
Wheelbase Length 278.89 cm
Standard Seating 5
Engine & Performance
Engine 3.5-L V-6
Engine Size 3.5L
Engine Cylinders 6
Transmission 8-Speed Automatic
Transmission Type Automatic
Transmission Speeds 8-Speed
Drivetrain All-Wheel Drive
Additional Features
Anti-Brake System 4-Wheel ABS
Steering Type Rack & Pinion
Pricing
Manufacturer Suggested Retail Price (MSRP) $50,975 USD
Invoice Price $47,730 USD
Delivery Charges $1,025 USD

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What Problems Does the 2021 Lexus RX 350 Have?

The 2021 Lexus RX 350 generally enjoys a strong reputation for reliability, consistent with Lexus's overall brand image. However, like any vehicle, it has had some reported issues and recalls. One area of concern that has been noted in previous model years, and could potentially carry over, is the infotainment system's user interface, specifically the Remote Touch controller, which some owners find less intuitive than a touchscreen. While not a mechanical failure, it can lead to driver distraction. Another area occasionally mentioned is the powertrain's acceleration, which some critics and owners find adequate but not particularly exhilarating, especially when compared to some competitors.

For the 2021 model year specifically, there were a few safety recalls. One significant recall involved the fuel pump, where the impeller could crack and fail, leading to a loss of power or stalling. Another recall addressed potential issues with the braking system. Long-term reliability for Lexus vehicles is typically excellent, and the RX 350 is a prime example. Owners who adhere to the recommended maintenance schedule can expect many years and miles of dependable service. The V6 engine and 8-speed automatic transmission are well-established and robust. While specific model year issues are less common for the RX 350 in recent generations, it's always advisable for potential buyers to check for any outstanding recalls or service bulletins pertaining to the specific vehicle they are considering. Generally, the RX 350 is known for avoiding major widespread mechanical defects that plague some other luxury brands.

How long will the 2021 Lexus RX 350 last?

Based on owner data and Lexus's reputation for longevity, the 2021 Lexus RX 350 is expected to provide reliable service for an average of 200,000 to 250,000 miles, with many examples exceeding 300,000 miles when properly maintained. Its long-term durability is a significant selling point. The robust V6 engine and proven drivetrain components contribute to this longevity. Weaknesses that might arise over time are typically minor and related to wear and tear on components like suspension bushings or interior trim, rather than major mechanical failures. Regular oil changes, fluid checks, and following the factory maintenance schedule are crucial for maximizing its lifespan and ensuring continued reliability.

What Technology & Safety Features are Included?

The 2021 Lexus RX 350 comes equipped with a user-friendly technology and safety suite. Standard tech features include an 8-inch touchscreen infotainment system, which is compatible with Apple CarPlay and Android Auto, allowing seamless smartphone integration. A 12-speaker Lexus premium audio system is also standard. For those seeking a more immersive audio experience, an optional 15-speaker Mark Levinson surround sound system is available.

The RX 350 also includes a comprehensive suite of advanced driver-assistance systems (ADAS) as standard, known as Lexus Safety System+ 2.0. This includes a Pre-Collision System with Pedestrian Detection, Dynamic Radar Cruise Control, Lane Departure Alert with Steering Assist, and Lane Tracing Assist. Additionally, standard features include automatic high beams and a rearview camera. Optional safety and convenience features include front and rear parking sensors, a panoramic view monitor, a color-keyed rear-seat entertainment system, and a wireless charging pad.

The infotainment interface, while featuring Apple CarPlay and Android Auto, utilizes a Remote Touch controller on the center console, which some users find less intuitive than a pure touchscreen. An optional navigation system can be added for enhanced mapping capabilities.

In terms of safety, the 2021 Lexus RX 350 performed well in crash tests. It received an overall rating of 5 stars from the National Highway Traffic Safety Administration (NHTSA). The Insurance Institute for Highway Safety (IIHS) awarded the 2021 RX 350 its highest rating of 'Good' in all six crashworthiness tests, earning it a Top Safety Pick designation. These accolades underscore the vehicle's strong safety credentials.

What Colors Options are Available?

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In the meantime, feel free to explore the other sections for more content.

2021 Lexus RX 350 Prices and Market Value

When new, the 2021 Lexus RX 350 had a starting MSRP of around $45,000 for the base model, with higher trims like the F SPORT and RX 350L commanding prices in the mid-$50,000s. Currently, the used market for a 2021 Lexus RX 350 typically ranges from approximately $35,000 to $45,000, depending on mileage, condition, trim level, and optional features. The RX 350 generally experiences a moderate depreciation rate, holding its value relatively well due to Lexus's strong reputation for reliability and luxury. Factors that positively affect resale value include a comprehensive maintenance history, low mileage, desirable trim levels (like the F SPORT), and the presence of sought-after optional packages.

2021 Lexus RX 350 Cost of Ownership

The 2021 Lexus RX 350 is generally considered moderately economical to own for a luxury SUV. Insurance costs will be typical for a luxury vehicle, influenced by location, driver history, and coverage. Fuel costs are reasonable, with its V6 engine achieving competitive MPG figures for its class. Maintenance costs are also generally lower than many European luxury competitors, thanks to Lexus's renowned reliability. Routine servicing is straightforward, and major repair costs are often less severe. While not as cheap to own as a non-luxury vehicle, its strong resale value and lower repair frequency make it a cost-effective luxury choice in the long run.

2021 Lexus RX 350 Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 41.15 liters
City Mileage 5.27 km/l
Highway Mileage 3.83 km/l

2021 Lexus RX 350 Safety Rating

NHTSA
Overall Rating
Overall Frontal Star Rating
Side Overall Star Rating
Overall Rollover Star Rating
Combined Front Seat Rating
Combined Rear Seat Rating
Overall Frontal Star Rating
Frontal Barrier Star Ratings Not Tested
Overall Side Star Rating
Side Barrier Star Ratings
Side Pole Star Rating
Combined Side Barrier And Side Pole Star Ratings Not Tested
Rollover Resistance Star Rating

2021 Lexus RX 350 Recalls & Defects

AIR Bags:sensor:occupant Classification
Recall date 2023-12-20
Recall no. 23v865000
Source NHTSA
Summary Toyota Motor Engineering & Manufacturing (Toyota) IS Recalling Certain 2020-2021 Avalon, Avalon Hybrid, Corolla, Highlander, Highlander Hybrid, Rav4, Rav4 Hybrid, Lexus Es350, Lexus Rx350, Lexus Rx450h, 2021 Sienna Hybrid, Lexus Es250, 2020-2022 Camry, Camry Hybrid, and Es300h Vehicles. A Short Circuit MAY Develop IN THE Occupant Classification System (Ocs) Sensor, Preventing THE Front Passenger AIR BAG From Deploying.
Consequence AN AIR BAG That Does NOT Deploy During A Crash Increases THE Risk OF Injury.
Remedy Dealers Will Inspect and Replace THE Sensor AS Necessary, Free OF Charge. Owner Letters Were Mailed October 31, 2024. This IS A Phased Recall. THE Next Phase IS Anticipated IN June 2025. Multiple Phases ARE Planned Through 2026. Owners MAY Contact Toyota Customer Service AT 1-800-331-4331. Toyota's Number FOR This Recall IS 23tb15/23ta15 Lexus 23lb03/23la03.
Notes Owners MAY Also Contact THE National Highway Traffic Safety Administration Vehicle Safety Hotline AT 1-888-327-4236 (Tty 1-800-424-9153), or GO TO Www.nhtsa.gov.

2021 Lexus RX 350 Warranty

Basic
Original warranty 48 months / 50,000 miles
Estimated remaining Expired
Powertrain
Original warranty 72 months / 70,000 miles
Estimated remaining 24 months / 70,000 miles
Rust
Original warranty 72 months / unlimited miles
Estimated remaining 24 months / unlimited miles

2021 Lexus RX 350 Insurance

Insurance for a 2021 Lexus RX 350 is moderately priced, reflecting its status as a Sport Utility Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2021 Lexus RX 350 Compare to Other Sport Utility Vehicle?

The 2021 Lexus RX 350 competes in the crowded mid-size luxury SUV segment against rivals like the Acura MDX, BMW X5, Audi Q7, and Volvo XC90.

Performance: The RX 350's 295-hp V6 is smooth but lacks the punch of some competitors. The BMW X5 and Audi Q7 often offer more powerful engine options and sportier handling. The Acura MDX also provides a more engaging driving experience.

Features: The RX 350 comes well-equipped with standard safety features and a decent infotainment system, though its Remote Touch controller is a point of contention. Competitors like the Audi Q7 and Volvo XC90 offer more advanced infotainment systems and a greater array of high-tech features. The Acura MDX has also upped its game with a modern interior and intuitive tech.

Reliability: This is where the RX 350 truly shines. It consistently ranks at the top for reliability, significantly outperforming many European rivals in long-term dependability studies. The Acura MDX is also known for strong reliability.

Price: The RX 350 typically offers a slightly lower starting price than many of its German rivals, providing good value for its luxury quotient.

Alternatives:
  • Acura MDX: A strong all-around competitor offering a more engaging drive, a spacious interior, and excellent reliability. If driving dynamics are a priority, the MDX is a great choice.
  • BMW X5: For those prioritizing performance and luxury, the X5 offers more potent engines and superior handling, but at a higher price and with potentially higher maintenance costs.
  • Volvo XC90: If safety and a sophisticated, minimalist interior are paramount, the XC90 is an excellent option, though its long-term reliability may not match the Lexus.
In summary, the 2021 RX 350 is an excellent choice for buyers prioritizing comfort, a quiet ride, and bulletproof reliability over outright performance or cutting-edge tech. If those are your priorities, it's a superior choice in its segment.

Final Verdict: Is the 2021 Lexus RX 350 a Good Sport Utility Vehicle?

The 2021 Lexus RX 350 is ideal for buyers who value long-term reliability, a supremely comfortable and quiet ride, and a refined interior over sporty driving dynamics. It's a strong contender for families and individuals seeking a dependable luxury SUV that depreciates moderately and incurs lower ownership costs compared to many rivals.

It is absolutely worth buying, especially on the used market where it represents excellent value. Buying used is often recommended due to the significant depreciation from new. The base RX 350 offers a robust package for most buyers. The RX 350L is suitable for those who occasionally need a third row, but its compromises should be considered. The F SPORT trim adds aesthetic appeal and sportier suspension but doesn't fundamentally transform its performance character. Overall, the RX 350 is a pragmatic and luxurious choice for those prioritizing comfort and dependability.

2021 Lexus RX 350 Owner Reviews

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Eugene S

Eugene is an automotive enthusiast with over 15 years of experience in the used car market. As a writer at VINCheck.info, he brings deep industry insight and a passion for cars, helping readers make smart, informed decisions. Eugene has written hundreds of used car reviews and is known for breaking down complex automotive topics into clear, actionable advice. Over the years, he has driven and worked on a wide range of vehicles—starting with tuning street cars in his early days and eventually focusing on performance upgrades and reliability improvements. Today, he specializes in evaluating used vehicles through the lens of real-world ownership and enthusiast needs. A longtime fan of Porsche, Eugene especially appreciates vehicles that blend durability with driving enjoyment.