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2010 Lexus RX 350 Overview, Reviews, Ratings & Specs

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Simon A | September 24, 2025
The 2010 Lexus RX 350 introduced the third generation of Lexus's highly successful mid-size luxury crossover SUV. This model year marked a significant update, building on its reputation for refinement and reliability. Available as the RX 350 (gasoline) or RX 450h (hybrid), it typically started in the upper $30,000s when new. It stands out for its exceptionally smooth ride, quiet cabin, premium interior materials, and legendary long-term dependability, making it a perennial favorite among luxury SUV buyers.
The Good

The 2010 Lexus RX 350 offers a smooth, capable 3.5L V6 engine and class-leading reliability, appealing to practical buyers. Its exceptionally comfortable and quiet cabin, coupled with a refined ride, provides an emotional sense of luxury. Excellent build quality, decent fuel efficiency for its class, and strong resale value further cement its appeal as a smart, long-term investment.

The Bad

While generally robust, the 2010 Lexus RX 350 has a few known weaknesses. Some owners find its steering and handling less engaging than sportier rivals. The Remote Touch infotainment controller can be polarizing, and the interior tech might feel dated compared to newer vehicles. Early third-generation models sometimes experienced issues with dashboard melting or stickiness, a common Toyota/Lexus issue of that era.

2010 Lexus RX 350: Quick Overview

  • Engine: 3.5-liter DOHC 24-valve V6 (2GR-FE)

  • Horsepower: 275 hp @ 6,200 rpm

  • Torque: 248 lb-ft @ 4,700 rpm

  • Transmission: 6-speed automatic transmission with sequential shift mode

  • Drivetrain: Front-Wheel Drive (FWD) standard, All-Wheel Drive (AWD) optional

  • Fuel Economy (EPA Estimated):
        
    • FWD: 18 mpg city / 25 mpg highway / 20 mpg combined

    • AWD: 18 mpg city / 24 mpg highway / 20 mpg combined

  • 0-60 mph Acceleration: Approximately 7.1-7.4 seconds

  • Towing Capacity: Up to 3,500 pounds when properly equipped with the towing prep package

  • Key Trim-Level Features (RX 350):
        
    • Standard Features: 18-inch alloy wheels, automatic headlights, foglights, LED taillights, privacy glass, a power liftgate, 10-way power driver's seat, 8-way power front passenger seat, dual-zone automatic climate control, a tilt-and-telescoping steering wheel, a sliding and reclining rear seat, cruise control, Bluetooth phone connectivity, and a nine-speaker sound system with a six-CD changer, auxiliary audio jack, and satellite radio.

    • Notable Optional Features (often bundled into packages): Leather upholstery, heated and ventilated front seats, a panoramic sunroof, 19-inch wheels, a navigation system with Lexus's Remote Touch controller and a rearview camera, a premium 12-speaker audio system, a 15-speaker Mark Levinson surround-sound audio system, rear-seat entertainment system, adaptive headlights, intuitive parking assist, and a pre-collision system with adaptive cruise control.

2010 Lexus RX 350 Specifications

Vehicle Information
Year 2010
Make Lexus
Model RX 350
Trim -
Style 4-Door All-Wheel Drive
Type Sport Utility Vehicle
Category -
Manufacturing Details
Made In -
Manufacturing City -
Dimensions
Doors 4-Door
Curb Weight 1969.95 kg
Gross Vehicle Weight Rating -
Overall Height 171.96 cm
Overall Length 477.01 cm
Overall Width 188.47 cm
Wheelbase Length 274.07 cm
Standard Seating 5
Engine & Performance
Engine Gasoline V-6 3.5L/211
Engine Size 3.5L
Engine Cylinders 6
Transmission 6-Speed Automatic
Transmission Type Automatic
Transmission Speeds 6-Speed
Drivetrain All-Wheel Drive
Additional Features
Anti-Brake System 4-Wheel ABS
Steering Type -
Pricing
Manufacturer Suggested Retail Price (MSRP) -
Invoice Price -
Delivery Charges -

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What Problems Does the 2010 Lexus RX 350 Have?

The 2010 Lexus RX 350 generally boasts excellent long-term reliability, a hallmark of the Lexus brand. However, like any vehicle, it's not without some frequently reported problems and potential concerns for used buyers. One of the most talked-about issues for this generation, and other Toyota/Lexus models of the same era, is the phenomenon of a sticky or melting dashboard. Over time and exposure to sunlight, the dashboard material can become tacky to the touch and develop a shiny, melted appearance. This is primarily a cosmetic issue but can be quite unsightly and costly to repair without aftermarket solutions. Some owners have also reported minor electrical gremlins, such as issues with power windows, mirrors, or dashboard lights, though these are less widespread than the dashboard problem.

Another area to watch is the power liftgate motor, which can sometimes fail, requiring replacement. While the 3.5L V6 engine and 6-speed automatic transmission are largely robust, regular maintenance is crucial to prevent premature wear. Suspension components, such as struts and bushings, will eventually wear out, especially on higher mileage examples, leading to a less composed ride or noise over bumps.

Regarding recalls, the 2010 Lexus RX 350 was notably included in several important campaigns. It was part of the widespread Takata airbag inflator recalls, which affected millions of vehicles globally and necessitated the replacement of specific airbag modules. Owners should always verify that these critical recalls have been addressed for any used vehicle they consider. Additionally, some 2010 RX 350 models were subject to a recall concerning floor mat interference with the accelerator pedal, a safety measure to prevent unintended acceleration. Always check the vehicle's VIN against NHTSA's recall database to ensure all outstanding campaigns have been completed.

How long will the 2010 Lexus RX 350 last?

With proper and consistent maintenance, a 2010 Lexus RX 350 can easily achieve 200,000 to 250,000 miles, and many owners report even higher mileage. It's not uncommon to see these vehicles providing 15 or more years of reliable service. The long-term durability is exceptional, largely due to its robust 3.5L V6 engine and durable 6-speed automatic transmission, which are among the most reliable powertrains on the market. Key weaknesses over time typically involve common wear items like suspension bushings, control arms, and eventually, the power steering pump. The aforementioned sticky dashboard issue is a cosmetic concern that tends to worsen with age and sun exposure. Regular fluid changes, including transmission fluid, are vital for maximizing its lifespan, reinforcing its reputation as a "set it and forget it" luxury SUV for many years.

What Technology & Safety Features are Included?

The 2010 Lexus RX 350, being a luxury vehicle, offered a solid array of technology, entertainment, and safety features for its time. Standard tech included Bluetooth phone connectivity and an auxiliary audio jack, with a USB port often available as an option. The most notable built-in tech was the optional navigation system, which introduced Lexus's innovative yet sometimes polarizing Remote Touch controller. This joystick-like device managed infotainment functions on a crisp, dash-mounted screen. While it offered haptic feedback and precise control, some users found it distracting to operate while driving.

For entertainment, a nine-speaker audio system with a six-CD changer and satellite radio was standard. Audiophiles could upgrade to a premium 12-speaker system or the top-tier 15-speaker Mark Levinson surround-sound system, which delivered exceptional audio quality. A rear-seat entertainment system with dual screens was also an available option, perfect for keeping passengers occupied on long journeys.

In terms of driver-assistance, standard features included antilock brakes (ABS), stability control, and traction control. Advanced optional features, less common but available, included adaptive headlights that swiveled with steering input, intuitive parking assist (parking sensors), and a pre-collision system bundled with adaptive cruise control. A rearview camera was integrated with the optional navigation system, aiding in parking and safety.

Safety was a strong point, with the RX 350 featuring 10 airbags as standard: front, side curtain, front side-impact, and front knee airbags for both driver and passenger. The vehicle performed commendably in crash tests:
  • IIHS (Insurance Institute for Highway Safety): Earned "Good" ratings (the highest possible) in frontal-offset, side-impact, and roof-strength tests.

  • NHTSA (National Highway Traffic Safety Administration): Under the pre-2011 rating system, the 2010 RX 350 received 5 out of 5 stars for frontal crash (driver), 4 out of 5 stars for frontal crash (passenger), 5 out of 5 stars for side crash (front seat), 5 out of 5 stars for side crash (rear seat), and 4 out of 5 stars for rollover resistance.

What Colors Options are Available?

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2010 Lexus RX 350 Prices and Market Value

When new, the 2010 Lexus RX 350 had a starting MSRP of approximately $37,625 for the FWD model and around $39,025 for the AWD version, before options and destination charges. Fast forward to today, and current used market prices typically range from $8,000 to $15,000, depending heavily on factors like mileage, overall condition, maintenance history, and the presence of desirable options such as navigation or the Mark Levinson audio system.

The RX 350 demonstrates excellent depreciation insights; it holds its value remarkably well compared to many luxury competitors. Lexus vehicles are renowned for their slow depreciation rates, making them smart long-term investments. Key factors affecting its strong resale value include its legendary reliability, the brand's reputation for quality, and continued demand for comfortable and dependable luxury crossovers. A well-maintained RX 350 with lower mileage will always command a premium.

2010 Lexus RX 350 Cost of Ownership

The 2010 Lexus RX 350 generally presents a balanced cost of ownership, leaning towards economical for a luxury SUV. Insurance costs are typically moderate, often less than comparable European luxury brands. Fuel consumption, requiring regular unleaded gasoline, is decent for its class, averaging around 20-22 MPG combined. Maintenance is more affordable than German rivals but slightly higher than mainstream Toyota models due to Lexus-specific parts and labor rates. However, its outstanding reliability means repairs are infrequent. When repairs are needed, parts can be pricier, but the infrequency of major issues makes long-term ownership surprisingly cost-effective. Overall, it's a relatively economical luxury vehicle to own, especially considering its premium nature and durability.

2010 Lexus RX 350 Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 72.68 liters
City Mileage 7.65 km/l
Highway Mileage 10.2 km/l

2010 Lexus RX 350 Insurance

Insurance for a 2010 Lexus RX 350 is moderately priced, reflecting its status as a Sport Utility Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2010 Lexus RX 350 Compare to Other Sport Utility Vehicle?

The 2010 Lexus RX 350 competes in a competitive segment against rivals like the Acura MDX, BMW X5, Mercedes-Benz ML350, Audi Q5, and Infiniti FX35 (later QX70).

In terms of Performance, the RX 350 offers a smooth, quiet, and adequately powerful V6 engine focused on comfort rather than outright sportiness. It delivers a plush ride but lacks the sharp handling dynamics of a BMW X5 or Infiniti FX35, which cater to a more enthusiastic driver. The Acura MDX strikes a balance, offering more engaging handling than the RX while maintaining good comfort.

Regarding Features, the RX 350 provides a premium, well-appointed cabin with high-quality materials. It emphasizes user-friendliness and a serene environment. While its optional tech, like the Remote Touch controller, was advanced for its time, it might feel less intuitive or cutting-edge compared to the infotainment systems found in a BMW or Audi from the same period, which often prioritized more complex, driver-focused controls.

Reliability is where the RX 350 truly shines, often outperforming its European rivals significantly. Its Toyota engineering foundation gives it a legendary reputation for dependability, typically resulting in fewer unscheduled repairs and lower long-term ownership headaches compared to the X5 or ML350. The Acura MDX also boasts strong reliability, making it a close competitor in this regard.

In terms of Price, both new and on the used market, the RX 350 often presents a more accessible entry point into luxury compared to many German competitors, particularly considering its strong resale value and lower depreciation.

Similar or Better Alternatives:
  • Acura MDX: A strong alternative offering more sporty handling, optional third-row seating, and comparable reliability, making it a more versatile choice for some.

  • Infiniti FX35/QX50: For buyers prioritizing a sportier driving experience and distinctive styling, the FX35 offers more aggressive performance at the expense of some ride comfort.

  • Toyota Highlander: A more budget-friendly, less luxurious alternative that shares much of the RX's underlying reliability and practicality, ideal for those who value function over luxury badges.

Final Verdict: Is the 2010 Lexus RX 350 a Good Sport Utility Vehicle?

The 2010 Lexus RX 350 is ideal for buyers prioritizing a supremely comfortable, quiet, and exceptionally reliable luxury crossover. It's perfect for families, commuters, or anyone seeking a premium vehicle with minimal ownership fuss and a strong sense of serenity. It might not satisfy enthusiasts looking for sporty handling, but it excels as a refined daily driver.

As a used vehicle, the 2010 RX 350 is absolutely worth buying. Its legendary reliability and slower depreciation make it an excellent value proposition. When considering one, look for models with a comprehensive service history to ensure consistent maintenance. Inspect the dashboard for the common sticky/melting issue, and ensure all Takata airbag recalls have been addressed. The AWD model offers enhanced traction in adverse weather, while opting for models with the Mark Levinson audio and navigation (if you can tolerate the Remote Touch controller) enhances the luxury experience. Its blend of luxury, dependability, and value makes it a smart used SUV choice.

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Simon A

Simon is a contributor to VinCheck, where he provides articles and reviews on various automotive topics. His work focuses on delivering accurate and up-to-date information about used cars, helping readers make informed decisions.