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2022 Lexus RX 350 Overview, Reviews, Ratings & Specs

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Cathleen V | September 24, 2025
The 2022 Lexus RX 350 is a mid-size luxury SUV, part of the acclaimed fourth generation (2016-2022) of Lexus's pioneering crossover. Available in RX 350, F Sport, and three-row RX 350L trims, new pricing ranged from approximately $45,000 to $55,000. It stands out for its exceptional reliability, refined ride quality, upscale interior, and strong resale value, making it immensely popular among luxury SUV buyers.
The Good

The RX 350 offers legendary Lexus reliability and a supremely comfortable, quiet ride, appealing to practical buyers seeking peace of mind. Its elegant design and luxurious interior evoke emotional appeal. With respectable V6 performance, decent fuel efficiency, and strong resale value, it offers an economical, premium ownership experience that's hard to beat.

The Bad

Potential weaknesses include the somewhat finicky Remote Touch infotainment controller, which can be distracting. Its driving dynamics prioritize comfort over sportiness, making it less engaging than some rivals. The optional third row in the RX 350L is quite cramped for adults, and cargo space is average for the segment.

2022 Lexus RX 350: Quick Overview

  • Engine: 3.5-liter V6, naturally aspirated.
  • Horsepower: 295 hp.
  • Fuel Economy (EPA Estimated):
    - FWD: 20 MPG city / 27 MPG highway / 23 MPG combined
    - AWD: 19 MPG city / 26 MPG highway / 22 MPG combined
  • 0-60 MPH: Approximately 7.7 seconds (FWD).
  • Towing Capacity: Up to 3,500 lbs when properly equipped.
  • Trim-Level Features:
    • RX 350 (Base): Standard features include an 8-inch touchscreen infotainment system with Apple CarPlay, Android Auto, and Amazon Alexa compatibility, the full suite of Lexus Safety System+ 2.0 driver-assistance features (Pre-Collision System, Lane Tracing Assist, Dynamic Radar Cruise Control, etc.), 18-inch alloy wheels, dual-zone automatic climate control, synthetic leather upholstery (NuLuxe), a power liftgate, and LED headlights.
    • RX 350 F Sport: Enhances the base trim with a more aggressive exterior styling (unique front and rear fascias, grille, and 20-inch alloy wheels), a sport-tuned adaptive variable suspension (AVS), F Sport bolstered front seats, a perforated leather-trimmed steering wheel with paddle shifters, and unique interior trim accents.
    • RX 350L (3-Row): Offers extended length to accommodate a power-folding third row of seating, allowing for up to seven passengers. It generally mirrors the features of the RX 350 but with a focus on family utility.
    • Optional Features: Across trims, notable optional features include a larger 12.3-inch touchscreen with navigation, a 15-speaker Mark Levinson premium audio system, a panoramic moonroof, a head-up display, heated and ventilated front seats, a 360-degree panoramic view monitor, and a premium triple-beam LED headlamp upgrade.

2022 Lexus RX 350 Specifications

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Model RX 350
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What Problems Does the 2022 Lexus RX 350 Have?

The 2022 Lexus RX 350 upholds Lexus's stellar reputation for reliability, making widespread, frequently reported mechanical problems uncommon. Owners consistently praise its durability and trouble-free operation. For the fourth generation (2016-2022), general observations, rather than severe defects, have sometimes included minor infotainment system quirks. The Remote Touch interface, while functional, can be polarizing and occasionally buggy, with some users reporting minor freezing or a steep learning curve. However, these are generally software-related and less severe than mechanical failures. Minor interior rattles or squeaks have been reported by a small number of owners across various model years, which is not uncommon for any vehicle. Brake pad wear might be quicker for some drivers depending on habits, but this isn't a manufacturing defect.

As for recalls, specific to the 2022 model year, significant safety-related or widespread mechanical recalls have been remarkably few, if any, according to major safety agencies at the time of this writing. Lexus vehicles, including the RX, are generally proactive in addressing any potential issues quickly. Long-term reliability concerns for the RX 350 are minimal; the 3.5L V6 engine and automatic transmission are well-proven and robust. With proper maintenance, these vehicles are known to exceed 200,000 to 250,000 miles without major powertrain issues, reinforcing the RX 350's status as one of the most dependable luxury SUVs on the market.

How long will the 2022 Lexus RX 350 last?

The 2022 Lexus RX 350 is renowned for its exceptional long-term durability, with many owners reporting their vehicles easily exceeding 200,000 to 250,000 miles, and often providing 15 or more years of reliable service with proper maintenance. The robust 3.5L V6 engine and automatic transmission are cornerstones of its longevity, rarely presenting major issues. Long-term weaknesses are typically minor, like wear on suspension components (bushings, struts) around the 100,000 to 150,000-mile mark, which is normal for any vehicle. Interior materials generally hold up very well, though some creasing on leather seats can occur on higher-mileage examples. The infotainment system, while reliable, may eventually feel dated compared to newer tech. Overall, its build quality and engineering ensure very low instances of catastrophic failures, making it a very durable choice for extended ownership.

What Technology & Safety Features are Included?

The 2022 Lexus RX 350 integrates a solid array of technology, entertainment, and safety features.

Infotainment and Entertainment: Standard is an 8-inch touchscreen display, compatible with Apple CarPlay, Android Auto, and Amazon Alexa, controllable via the intuitive-yet-sometimes-polarizing Remote Touch Interface (a trackpad). It includes a 9-speaker audio system, Bluetooth connectivity, and multiple USB ports. Buyers can upgrade to a more expansive 12.3-inch touchscreen with integrated navigation and a premium 15-speaker Mark Levinson surround sound audio system, providing an immersive listening experience.

Driver-Assistance & Safety Features: All 2022 RX 350 models come standard with the comprehensive Lexus Safety System+ 2.0. This suite includes the Pre-Collision System with Pedestrian and Bicycle Detection, Lane Tracing Assist, Lane Departure Alert with Steering Assist, All-Speed Dynamic Radar Cruise Control, Intelligent High Beams, and Road Sign Assist. Optional safety features or those bundled in higher trims include a Blind Spot Monitor with Rear Cross-Traffic Alert, a Panoramic View Monitor (360-degree camera), and Intuitive Parking Assist with Automatic Braking.

Crash-Test Ratings: The 2022 Lexus RX 350 received commendable safety ratings. The Insurance Institute for Highway Safety (IIHS) designated it a "TOP SAFETY PICK" when equipped with specific headlights, earning "Good" ratings in all six crashworthiness tests and "Superior" ratings for both vehicle-to-vehicle and vehicle-to-pedestrian front crash prevention. The National Highway Traffic Safety Administration (NHTSA) awarded the 2022 RX 350 a 5-star overall safety rating, with 5 stars for frontal crash, 5 stars for side crash, and 4 stars for rollover resistance, underscoring its robust protective capabilities.

What Colors Options are Available?

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In the meantime, feel free to explore the other sections for more content.

2022 Lexus RX 350 Prices and Market Value

When new, the 2022 Lexus RX 350 started around $45,970 for the FWD model, with AWD and F Sport trims reaching into the low to mid-$50,000s. As of early 2024, current used market prices for a 2022 RX 350 typically range from $38,000 to $50,000+, depending on mileage, condition, and optional equipment.

The RX 350 exhibits exceptionally strong depreciation performance, holding its value significantly better than most luxury competitors. This low depreciation is a major advantage for owners. Factors affecting its robust resale value include Lexus's legendary reliability, consistent high consumer demand for luxury crossovers, excellent build quality, and a reputation for lower long-term ownership costs. Well-maintained vehicles with complete service records, lower mileage, and desirable option packages (like the larger infotainment screen or premium audio) command the highest used prices, making it a sound investment both new and used.

2022 Lexus RX 350 Cost of Ownership

Ownership costs for the 2022 Lexus RX 350 are notably reasonable for a luxury SUV. Insurance premiums are generally moderate, thanks to its strong safety ratings and lower theft rates compared to some rivals. Fuel costs are average for its class, with the V6 engine requiring regular gasoline and achieving around 22 MPG combined. Maintenance expenses are typically lower than German luxury vehicles, with parts and labor being competitive. Repair costs are historically very low, as the RX 350 is renowned for its reliability, meaning fewer unexpected issues. Overall, the 2022 Lexus RX 350 is considered quite economical to own in the long term, offering premium luxury without the premium ownership headaches often associated with the segment.

2022 Lexus RX 350 Fuel Efficiency

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2022 Lexus RX 350 Safety Rating

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2022 Lexus RX 350 Insurance

Insurance for a 2022 Lexus RX 350 is moderately priced, reflecting its status as a Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2022 Lexus RX 350 Compare to Other Vehicle?

The 2022 Lexus RX 350 competes in a crowded luxury mid-size SUV segment against formidable rivals like the Acura MDX, BMW X5, Mercedes-Benz GLE, Audi Q7, and Genesis GV80.

Performance: The RX 350's 295-hp V6 offers smooth, adequate power and a comfortable, refined ride. However, it prioritizes luxury over sportiness. Rivals like the BMW X5 and Mercedes-Benz GLE offer more powerful engine options, sharper handling, and a more engaging driving experience for enthusiasts. The Acura MDX offers similar V6 power with a slightly sportier feel, while the Audi Q7 provides a balanced, composed ride.

Features: The RX 350 comes well-equipped with standard Lexus Safety System+ 2.0. Its interior is opulent and comfortable, though the Remote Touch infotainment controller can be polarizing. German rivals often boast more cutting-edge infotainment, more advanced customization options, and often a more modern cabin design, but typically at a higher price point. The Genesis GV80 offers an incredible array of luxury features and striking design at a very competitive price point.

Reliability: This is where the RX 350 truly shines, consistently leading its class in reliability ratings from J.D. Power and Consumer Reports. The Acura MDX is a close second in dependability. German competitors, while excellent, generally don't match Lexus's long-term reliability and typically incur higher maintenance and repair costs.

Price: The RX 350's new price falls in the mid-range of its luxury class, but its strong resale value and lower ownership costs make it an excellent value proposition. German rivals typically start higher and can become significantly more expensive with options. The Acura MDX is often similarly priced or slightly less, while the Genesis GV80 often provides more luxury features per dollar.

Recommendations:
  • For Sportiness/Driving Dynamics: BMW X5, Mercedes-Benz GLE, Audi Q7.
  • For Similar Reliability & Value: Acura MDX.
  • For Value Luxury with Bold Design: Genesis GV80.
  • For buyers prioritizing unwavering reliability, exceptional comfort, and strong resale value, the Lexus RX 350 remains a superior choice.

Final Verdict: Is the 2022 Lexus RX 350 a Good Vehicle?

The 2022 Lexus RX 350 is ideally suited for buyers who prioritize comfort, a plush and quiet ride, unwavering reliability, and strong resale value above all else. It's an excellent choice for families, empty-nesters, or anyone seeking a luxurious, low-stress daily driver.

It is absolutely worth buying, whether new or used. A new 2022 RX 350 offers full warranty coverage and the latest features, proving a sensible investment given its minimal depreciation. However, a well-maintained used 2022 model, or even a slightly older fourth-generation RX, represents an even more compelling value, providing nearly identical benefits at a significantly lower cost. Look for models with the larger infotainment screen if tech is a priority. The F Sport trim adds a touch of visual aggression and a firmer, yet still comfortable, ride for those desiring a sportier aesthetic. The RX 350L is suitable for occasional third-row use, though it remains tight for adults. Ultimately, it's a smart, reliable, and comfortable luxury SUV choice.

2022 Lexus RX 350 Owner Reviews

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Cathleen V

Cathleen is an exceptional freelance writer covering hot topics in the automotive world from a gearhead's perspective. Her articles delve into various aspects of automotive technology and history, offering readers detailed insights into engine performance, reliability, and maintenance. Through her engaging and informative writing, Cathleen provides valuable information to automotive enthusiasts and consumers alike, helping them make informed decisions about vehicle maintenance and purchases.