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2021 Mercedes-Benz E-Class Overview, Reviews, Ratings & Specs

Rating: 4.58
Based on 12 Owner Reviews â–¶
Drew B | March 31, 2025
The Mercedes-Benz E-Class, a long-standing symbol of luxury and refinement, offers a blend of performance, technology, and comfort. The 2021 model is part of the fifth generation (W213), available as a sedan, coupe, cabriolet, and wagon. Key trims include the E350, E450, and the high-performance AMG E63 S. New pricing ranged from approximately $55,000 to well over $110,000 for the AMG variant. It's popular for its sophisticated design, advanced technology, and comfortable ride, representing a benchmark in the mid-size luxury segment.
The Good

The 2021 E-Class excels in performance with potent engine options, offering thrilling acceleration, especially in AMG guise. Its elegant design and luxurious interior evoke emotional appeal. Practical buyers appreciate the car's comfortable ride, advanced safety features, and respectable fuel efficiency for its class. While not known for stellar reliability, it still offers a composed and refined driving experience.

The Bad

Potential weaknesses of the 2021 E-Class include its complex electronics, which can lead to glitches. Some owners have reported issues with the infotainment system and driver-assistance features. Repair costs can be high due to the car's sophisticated engineering and premium parts. Check for any signs of electrical problems and ensure all systems are functioning correctly before purchasing.

2021 Mercedes-Benz E-Class: Quick Overview

  • Engine Options:
    • E350: 2.0L Turbocharged Inline-4
    • E450: 3.0L Turbocharged Inline-6 with mild hybrid assist
    • AMG E63 S: 4.0L Handcrafted AMG Turbo V8
  • Horsepower:
    • E350: 255 hp
    • E450: 362 hp
    • AMG E63 S: 603 hp
  • Fuel Economy (EPA Estimated):
    • E350: 23 mpg city / 32 mpg highway
    • E450: 22 mpg city / 31 mpg highway
    • AMG E63 S: 16 mpg city / 23 mpg highway
  • 0-60 Times:
    • E350: Approximately 6.1 seconds
    • E450: Approximately 4.9 seconds
    • AMG E63 S: Approximately 3.3 seconds
  • Towing Capacity: Not recommended for towing.
  • Trim-Level Features:
    • E350: MB-Tex upholstery, 12.3-inch infotainment display, 12.3-inch digital instrument cluster, Apple CarPlay, Android Auto, LED headlights, sunroof, power front seats.
    • E450: All E350 features plus: more powerful engine, air suspension, available leather upholstery, upgraded sound system, and more optional packages.
    • AMG E63 S: All E450 features plus: handcrafted AMG engine, AMG performance exhaust system, AMG sport seats, AMG drive modes, upgraded brakes, and unique styling elements.
  • Additional Notes: All trims offer a wide array of optional packages that add features like massaging seats, premium audio systems, advanced driver-assistance technologies, and more luxurious interior appointments. The E-Class offers all-wheel drive (4MATIC) as an option on most trims, improving traction and handling, especially in inclement weather.

2021 Mercedes-Benz E-Class Specifications

Vehicle Information
Year 2021
Make Mercedes-Benz
Model E-Class
Trim -
Style -
Type Passenger Sedan
Category Mid-Size Station Wagon
Manufacturing Details
Made In Germany
Manufacturing City SINDELFINGEN
Dimensions
Doors 4-Door
Curb Weight -
Gross Vehicle Weight Rating -
Overall Height -
Overall Length -
Overall Width -
Wheelbase Length -
Standard Seating 7
Engine & Performance
Engine M177
Engine Size 4L
Engine Cylinders 8
Transmission 9-Speed Automatic
Transmission Type Automatic
Transmission Speeds 9-Speed
Drivetrain All-Wheel Drive
Additional Features
Anti-Brake System Standard
Steering Type -
Pricing
Manufacturer Suggested Retail Price (MSRP) -
Invoice Price -
Delivery Charges -

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What Problems Does the 2021 Mercedes-Benz E-Class Have?

Frequently reported problems for the 2021 Mercedes-Benz E-Class often revolve around the complex electronic systems. Some owners have reported glitches with the MBUX infotainment system, including screen freezes, connectivity issues, and software malfunctions. Driver-assistance features, such as lane keeping assist and adaptive cruise control, have also been known to experience occasional hiccups.

Specific recalls for the 2021 model year should be checked via the NHTSA website using the VIN. Common areas for recalls across various Mercedes-Benz models include potential issues with fuel pumps, airbags, and brake systems.

Long-term reliability can be a concern, particularly with the air suspension system (if equipped) and the potential for oil leaks in the engine. The AMG models, with their high-performance engines, may require more frequent maintenance and are potentially more susceptible to wear and tear over time. Regular maintenance and adherence to the manufacturer's recommended service schedule are crucial for mitigating potential problems. It's advisable to have a pre-purchase inspection performed by a qualified Mercedes-Benz mechanic to identify any existing or potential issues.

How long will the 2021 Mercedes-Benz E-Class last?

With proper maintenance, a 2021 Mercedes-Benz E-Class can reasonably be expected to provide 150,000 to 200,000 miles or 10-15 years of service. Long-term durability largely depends on adherence to scheduled maintenance and addressing minor issues promptly.

Weaknesses over time can include deterioration of rubber components, such as suspension bushings and seals, leading to potential leaks and ride quality degradation. The air suspension, if equipped, may require costly repairs as it ages. Keeping up with fluid changes (oil, transmission, coolant) is crucial for maximizing engine and drivetrain longevity. Models with more advanced technology may face obsolescence of certain features as newer technologies emerge.

What Technology & Safety Features are Included?

The 2021 Mercedes-Benz E-Class boasts a comprehensive suite of technology, entertainment, driver-assistance, and safety features. Standard tech includes the MBUX infotainment system with a 12.3-inch touchscreen display, a 12.3-inch digital instrument cluster, Apple CarPlay, and Android Auto. Entertainment options include a Burmester surround-sound system.

Standard driver-assistance features include active brake assist, blind-spot assist, and attention assist. Optional features include adaptive cruise control, lane-keeping assist, lane change assist, and evasive steering assist. These systems enhance safety and convenience, making driving less stressful.

Safety features include multiple airbags, anti-lock brakes, electronic stability control, and a rearview camera. Optional safety features include a surround-view camera system and a head-up display.

Crash-test ratings from the NHTSA and IIHS should be consulted for specific scores. The E-Class typically performs well in these tests, earning high marks for occupant protection. These safety technologies and strong crash performance make the E-Class a safe and reliable choice for drivers and passengers.

What Colors Options are Available?

Exterior Colors
Polar White
Obsidian Black Metallic
Selenite Grey Metallic
designo Diamond White Metallic
designo Cardinal Red Metallic
Mojave Silver Metallic
Cirrus Silver Metallic
Graphite Grey Metallic
Neva Grey
Twilight Blue Metallic
Emerald Green Metallic
Interior Colors
Black Nappa Leather
Espresso Brown/Black Nappa Leather
Macchiato Beige/Black Nappa Leather
Nut Brown/Black Nappa Leather
Classic Red/Black Nappa Leather
designo Black Nappa Leather
designo Macchiato Beige/Black Nappa Leather
designo Saddle Brown/Black Nappa Leather
Yacht Blue/Black Nappa Leather

2021 Mercedes-Benz E-Class Prices and Market Value

The 2021 Mercedes-Benz E-Class had a new MSRP ranging from around $55,000 for the base E350 to over $110,000 for a well-equipped AMG E63 S. Current used market prices vary greatly depending on mileage, condition, and trim level. Expect to find E350 models in the $35,000-$45,000 range, while AMG E63 S models can still command prices above $70,000.

Depreciation is typical for luxury vehicles. Factors affecting resale value include the car's condition, mileage, service history, and optional equipment. Models with desirable options and a clean history command higher prices. Low mileage and meticulous maintenance records can significantly improve resale value.

2021 Mercedes-Benz E-Class Cost of Ownership

The 2021 Mercedes-Benz E-Class is generally costly to own. Insurance premiums are higher due to the car's value and repair costs. Fuel costs vary depending on the engine, with the AMG E63 S being the most expensive. Maintenance, including scheduled servicing and potential repairs, can be substantial, as parts and labor are premium-priced. Long-term ownership requires budgeting for potential issues with electronics and air suspension. While not economical, the E-Class offers a luxurious experience that justifies the higher costs for some buyers.

2021 Mercedes-Benz E-Class Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 25 gallons
City Mileage 21 miles/gallon
Highway Mileage 29 miles/gallon

2021 Mercedes-Benz E-Class Safety Rating

NHTSA
Overall Rating
Overall Frontal Star Rating
Side Overall Star Rating
Overall Rollover Star Rating
Combined Front Seat Rating
Combined Rear Seat Rating
Overall Frontal Star Rating
Frontal Barrier Star Ratings Not Tested
Overall Side Star Rating
Side Barrier Star Ratings
Side Pole Star Rating
Combined Side Barrier And Side Pole Star Ratings Not Tested
Rollover Resistance Star Rating

2021 Mercedes-Benz E-Class Insurance

Insurance for a 2021 Mercedes-Benz E-Class is moderately priced, reflecting its status as a Passenger Sedan with strong safety ratings and
reasonable repair costs.

How Does the 2021 Mercedes-Benz E-Class Compare to Other Passenger Sedan?

The 2021 Mercedes-Benz E-Class competes with the BMW 5 Series, Audi A6, and Volvo S90. In terms of performance, the AMG E63 S rivals the BMW M5, offering blistering acceleration. The E-Class generally boasts a more luxurious and comfortable interior than the BMW 5 Series, but the BMW provides a more engaging driving experience. The Audi A6 offers similar levels of technology and comfort at a slightly lower price point but lacks the raw power of the AMG E63 S. The Volvo S90 prioritizes safety and Scandinavian design but lags behind in performance and brand prestige.

Reliability is a weak point for the E-Class compared to the Lexus GS (although the GS is discontinued, used models are available), which is known for its exceptional reliability. The Genesis G80 offers a similar level of luxury and features for a lower price, making it an attractive alternative.

For buyers prioritizing driving dynamics, the BMW 5 Series is a strong contender. For those seeking ultimate reliability, a used Lexus GS might be a better choice. If value is a primary concern, the Genesis G80 presents a compelling alternative.

Ranks #522 Sedan

1 2023 Toyota Camry (5.0★)
2 2023 Honda Accord (0.0★)
3 2023 Lexus ES (0.0★)
4 2024 Subaru Legacy (5.0★)
5 2022 Mazda MX-30 (5.0★)
6 2024 BMW M3 (0.0★)
7 2023 Ford Mustang (5.0★)
8 2023 Mercedes-Benz AMG GT (0.0★)
9 2023 Audi A3 (0.0★)
10 2023 Chevrolet Camaro (5.0★)
11 2023 Hyundai Elantra Hybrid (0.0★)
12 2023 Nissan Altima (4.0★)
522 2021 Mercedes-Benz E-Class (4.0★)

Final Verdict: Is the 2021 Mercedes-Benz E-Class a Good Passenger Sedan?

The 2021 Mercedes-Benz E-Class is ideal for buyers seeking a luxurious and technologically advanced mid-size sedan, coupe, cabriolet, or wagon. It's worth buying if you appreciate sophisticated design, a comfortable ride, and cutting-edge features. However, be prepared for potentially higher ownership costs. A used 2021 E-Class can offer significant savings compared to buying new, but a thorough pre-purchase inspection is essential.

Specific trims like the E450 offer a good balance of performance and comfort. The AMG E63 S is for those who prioritize exhilarating performance above all else. If reliability is a top concern, consider alternatives. Ultimately, the E-Class is a compelling choice if you value luxury, technology, and brand prestige, and are willing to accept the associated costs.

2021 Mercedes-Benz E-Class Owner Reviews

4.58
Consumer Rating, Based on 12 Consumer Reviews
Overall rating
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bobholt on January 20, 2024

Buy a 2014-2016 instead

Get a 2014-2016 instead. I owned a 2014 E350 for 7 years. I loved it. Someone t-boned it and it was totaled in 2022. I bought a 2021 E350, figuring it would be as good or better. NO WAY. The 2014 is part of a model line called W212 - it includes 2015 and 2016. After that, although OK, the model line is W213 (2017-2023) and it is not nearly as good. No spare, No CD player, annoying and misfiring touch controls, Voice commands misfire, way less front seat storage, and annoying transmission jerks on most of them. BUY A 2014-2016 E-class and you will not be sorry.

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P. Moore on May 29, 2022

Most unreliable car ever

2021 E450 Cabriolet: 7th new car from dealership. Delivered Dec 28, 2020. 1st month car was towed in. Took 2 months for new 48 v battery from Germany. Been towed in 6 more times because it wouldn’t start. Out of service over 3 months in last 15-16 months. In shop right now for 2 wks. Keep blaming “software problems “.

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1

Benz on May 20, 2021

Most beautiful car I have ever had

I love my car All the technology on it it’s like a dream Interiores are so beautifully design and comfortable Runs so smooth, I feel like a millionaire driving it🥰

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Mikeontherun on April 5, 2021

Very nice car so far

Owned for a month so far. Aside from a slight rattle occasionally in the passenger door everything is great. Still on the 1000 mile engine break-in but it is very quick. Gas mileage is running about 20 MPG in town and 29 on the highway. Very comfortable and feels very much like a luxury car. Traded in a 2016 Audi A6 which was also a very good car. The E450 just feels more luxurious and quicker. Slightly better steering feel as well.

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Allicoco on April 3, 2021

One of the best cars I’ve ever owned

The car rides great and looks good. I like the lines and response of the car. Nice color and the features are excellent. I recommend this dealership and car to everyone.

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0

Ken H. on March 25, 2021

This car is why you buy a Mercedes-Benz.

I'm replacing a 17 y/o E-320 that I loved. I am now infatuated with the New 2021 E-450 4 matic it just so happens to be the Motor Trend car of the year. Very nice exterior styling. Fantastic interior. all the latest technology and a great interior. The strait V-6 with turbo is smooth as silk. The optional Air Body control suspension makes for a fantastic smooth ride.

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0

Lovemybuckheadbenz on January 21, 2021

Love my Car

The vehicle meets all of my needs. I special ordered the vehicle with the color and leather interior I prefer. It arrived exactly the way I wanted.

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0

BurdieMD on December 31, 2020

A Starship Enterprise-type vehicle

It’s a well engineered vehicle from the steering wheel to the technical features, to the suspension, to the tires. The GPS is easy to use and much more efficient than previous versions.

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bobholt on January 20, 2024

Buy a 2014-2016 instead

Get a 2014-2016 instead. I owned a 2014 E350 for 7 years. I loved it. Someone t-boned it and it was totaled in 2022. I bought a 2021 E350, figuring it would be as good or better. NO WAY. The 2014 is part of a model line called W212 - it includes 2015 and 2016. After that, although OK, the model line is W213 (2017-2023) and it is not nearly as good. No spare, No CD player, annoying and misfiring touch controls, Voice commands misfire, way less front seat storage, and annoying transmission jerks on most of them. BUY A 2014-2016 E-class and you will not be sorry.

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0
1

P. Moore on May 29, 2022

Most unreliable car ever

2021 E450 Cabriolet: 7th new car from dealership. Delivered Dec 28, 2020. 1st month car was towed in. Took 2 months for new 48 v battery from Germany. Been towed in 6 more times because it wouldn’t start. Out of service over 3 months in last 15-16 months. In shop right now for 2 wks. Keep blaming “software problems “.

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Drew B

Drew is a seasoned automotive expert and contributor to VinCheck.info. With nearly 15 years of experience as a former Porsche technician, he brings a wealth of hands-on knowledge to his writing. Born in North Carolina, a region renowned for its deep-rooted NASCAR culture, Drew developed a passion for cars early in life, often building and working on vehicles from a young age. At VINCheck, Drew leverages his extensive technical background to provide in-depth analyses of various vehicles. His articles often focus on engine performance, reliability, and maintenance insights, offering readers practical information grounded in real-world experience. Some of his notable contributions include reviews on the Mazda CX-5's longevity and detailed examinations of engine options for models like the 2011 Toyota Camry and Tacoma