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2006 Mercedes-Benz S-Class Overview, Reviews, Ratings & Specs

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Drew B | September 26, 2025
The 2006 Mercedes-Benz S-Class, specifically the W220 generation's final model year, represents the pinnacle of luxury and technological innovation from its era. This full-size luxury sedan was produced from 1999-2006. Key trims included the S430, S500, S600, S55 AMG, and the mighty S65 AMG. Originally priced from around $75,000 to over $150,000, it stood out for its plush ride, advanced features like Airmatic suspension, and powerful engines, cementing its status as a benchmark for executive sedans.
The Good

Key advantages include its supremely comfortable and spacious cabin, class-leading ride quality thanks to Airmatic suspension, and powerful, smooth engines ranging from V8s to bi-turbo V12s. Its timeless, elegant design offers significant prestige. As a used vehicle, it presents remarkable value, offering immense luxury and advanced features for a fraction of its original cost, appealing to both emotional desires for status and practical needs for comfort on long journeys.

The Bad

Known weaknesses for the 2006 S-Class include costly and frequent failures of the Airmatic or Active Body Control (ABC) suspension systems. Electrical gremlins, such as issues with the COMAND infotainment system, window regulators, and various sensors, are common. High maintenance and repair costs, particularly for specialized components, are a significant consideration for prospective owners.

2006 Mercedes-Benz S-Class: Quick Overview

  • Engine Options:
    - S430: 4.3L V8
    - S500: 5.0L V8
    - S55 AMG: 5.4L Supercharged V8
    - S600: 5.5L Bi-turbo V12
    - S65 AMG: 6.0L Bi-turbo V12
  • Horsepower:
    - S430: Approximately 275 hp
    - S500: Approximately 302 hp
    - S55 AMG: Approximately 493 hp
    - S600: Approximately 493 hp
    - S65 AMG: Approximately 604 hp
  • Fuel Economy (EPA Estimates, varies by driving conditions and engine):
    - S430/S500: Roughly 16-17 MPG combined (14 city / 21-22 highway)
    - S55 AMG/S600/S65 AMG: Roughly 13-15 MPG combined (11-12 city / 17-19 highway)
  • 0-60 MPH Times (Approximate):
    - S430: Around 7.0 seconds
    - S500: Around 6.0 seconds
    - S55 AMG: Around 4.5 seconds
    - S600: Around 4.5 seconds
    - S65 AMG: Around 4.2 seconds
  • Towing Capacity: The S-Class is not designed or generally recommended for significant towing. Owners should consult their manual for any specific, very low capacity ratings, primarily for very light loads.
  • Trim-Level Features:
    - S430/S500: Standard luxury features included leather upholstery, automatic climate control, COMAND infotainment system with navigation, heated power front seats, power sunroof, Airmatic air suspension, and comprehensive safety features like ESP and multiple airbags.
    - S600: Added the powerful V12 engine, Active Body Control (ABC) hydraulic suspension, premium leather, exclusive wood trim, ventilated and massaging front seats, power rear sunshade, and generally more advanced comfort features.
    - S55 AMG/S65 AMG: Focused on performance with bespoke AMG-tuned engines, sport-tuned ABC suspension, high-performance braking systems, distinctive aerodynamic bodywork, larger wheels, and sportier interior accents while retaining most S600 luxury appointments. The S65 AMG featured the most potent bi-turbo V12 engine. Keyless-Go, PARKTRONIC, and Distronic adaptive cruise control were common options or standard on higher trims.

2006 Mercedes-Benz S-Class Specifications

Vehicle Information
Year 2006
Make Mercedes-Benz
Model S-Class
Trim -
Style 4-Door Sedan SWB 4.3-Liter
Type Sedan
Category Large Car
Manufacturing Details
Made In Germany
Manufacturing City SINDELFINGEN
Dimensions
Doors 4-Door
Curb Weight 1891.48 kg
Gross Vehicle Weight Rating -
Overall Height 144.53 cm
Overall Length 516.38 cm
Overall Width 185.42 cm
Wheelbase Length swb
Standard Seating 5
Engine & Performance
Engine 4.3-L V-8
Engine Size 4.3L
Engine Cylinders 8
Transmission Automatic
Transmission Type Automatic
Transmission Speeds 5-Speed
Drivetrain All-Wheel Drive
Additional Features
Anti-Brake System 4-Wheel ABS
Steering Type Rack & Pinion
Pricing
Manufacturer Suggested Retail Price (MSRP) $86,050 USD
Invoice Price $80,027 USD
Delivery Charges $775 USD

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Analysis

What Problems Does the 2006 Mercedes-Benz S-Class Have?

The 2006 Mercedes-Benz S-Class, while a marvel of engineering for its time, is notorious for several frequently reported problems, primarily concerning its complex systems. The most prominent and costly issue is the Airmatic air suspension system (standard on most models) or the even more sophisticated and expensive Active Body Control (ABC) hydraulic suspension (found on S600 and AMG models). Components like air springs, struts, compressors, valve blocks, and hydraulic pumps are prone to failure, leading to a sagging ride height and requiring very expensive repairs, often in the thousands of dollars per corner or system component.

Electrical system malfunctions are also common. Owners frequently report issues with the COMAND infotainment system (display failures, navigation glitches), window regulators failing, instrument cluster pixel degradation, battery drain, various sensor failures (e.g., crank position sensor, O2 sensors), and general wiring harness deterioration. The complexity of the electronics makes diagnostics and repairs challenging and costly.

While generally robust, the 722.6 automatic transmission can develop issues over time, especially if fluid changes are neglected. Common problems include rough shifts, delayed engagement, or valve body failures. Engine issues, such as oil leaks from valve cover gaskets or oil cooler seals, are also reported on higher-mileage examples.

Regarding recalls, for the W220 S-Class, specific recalls included potential issues with the wiper motor (some models), certain fuel pump relays, and minor electrical components. However, for the 2006 model year specifically, there weren't widespread, catastrophic safety recalls that define its ownership experience; rather, the concerns are largely wear-and-tear related to its advanced systems. Long-term reliability is primarily hampered by the sheer cost of parts and the specialized labor required to diagnose and fix these sophisticated problems, making it a demanding vehicle to maintain beyond its warranty period.

How long will the 2006 Mercedes-Benz S-Class last?

With meticulous and proactive maintenance, a 2006 Mercedes-Benz S-Class can reliably achieve 150,000 to 200,000 miles or more. The core engines and transmissions are often incredibly durable. However, the average ownership period for many is shorter due to the escalating repair costs of ancillary systems. Neglecting scheduled maintenance or deferring repairs drastically reduces its lifespan and reliability. Long-term durability is severely tested by the complex and expensive air or hydraulic suspension systems, which almost inevitably require significant repair or replacement. Electrical components, aging rubber and plastic parts, and interior wear also become more prevalent over time. Owners committed to its longevity must be prepared for continuous investment, focusing on preventative maintenance and addressing issues promptly to prevent cascading failures.

What Technology & Safety Features are Included?

The 2006 Mercedes-Benz S-Class was a technological tour de force for its time, setting benchmarks for luxury and convenience. Its central feature was the COMAND (Cockpit Management and Data) system, integrating navigation, radio, CD/DVD player, and vehicle settings via a dashboard screen and intuitive controls. High-end trims often featured a premium Harman Kardon Logic7 surround sound system. Other interior tech included multi-zone automatic climate control, heated and power-adjustable front seats, and a power rear sunshade.

For driver-assistance, it offered advanced features such as PARKTRONIC (front and rear parking sensors), rain-sensing wipers, automatic headlamps, and, notably, Distronic adaptive cruise control. This system could maintain a set distance from the vehicle ahead, a highly advanced feature for 2006. Keyless-Go, allowing keyless entry and ignition, was also available.

Safety was paramount, with a comprehensive suite of features. This included standard Anti-lock Braking System (ABS), Electronic Stability Program (ESP), and numerous airbags (front, side-impact, and window curtain airbags for head protection). Mercedes-Benz's pioneering PRE-SAFE system was standard, which could detect an impending collision and automatically pre-tension seatbelts, adjust front passenger seats, and close the sunroof and windows. The Tele Aid emergency call system provided automatic collision notification and roadside assistance.

Optional luxury features included ventilated and massaging front seats, a heated steering wheel, a rear seat package with heated and ventilated power-adjustable rear seats, and a panoramic sunroof. While the S-Class was engineered for exceptional occupant protection, specific crash-test ratings from modern agencies like NHTSA or IIHS for a 2006 model are generally not available. However, it was designed to meet and exceed the highest safety standards of its era, demonstrating robust structural integrity in real-world scenarios.

What Colors Options are Available?

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2006 Mercedes-Benz S-Class Prices and Market Value

When new in 2006, the S-Class had a broad pricing spectrum: the S430 started around $75,000-$80,000, the S500 around $85,000-$90,000, while the S600 commanded $120,000-$130,000, and the high-performance AMG models (S55 and S65) ranged from $110,000 to over $160,000. Today, current used market prices vary drastically, typically from $5,000 for high-mileage examples needing work, up to $15,000-$25,000+ for exceptionally well-maintained, lower-mileage S500s, S600s, or AMG variants.

Depreciation insights reveal a massive drop in value. Luxury sedans like the S-Class experience some of the steepest depreciation curves, making them accessible in the used market. Factors affecting current resale value include the vehicle's overall condition, documented maintenance history (crucial for these complex cars), mileage, and the specific trim level (V12 and AMG models hold slightly better value if pristine due to enthusiast demand, but their repair costs are higher). Geographic location and optional features also play a role.

2006 Mercedes-Benz S-Class Cost of Ownership

Owning a 2006 Mercedes-Benz S-Class is unequivocally costly. Insurance premiums are higher due to its luxury status, powerful engines, and expensive replacement parts. Fuel costs are significant; the V8 and V12 engines demand premium fuel and consume it readily, resulting in low MPG figures. Routine maintenance, requiring specialized fluids and filters, is expensive. Repair costs are exceptionally high; common issues like Airmatic/ABC suspension failures, electrical problems, or transmission work can easily run into thousands of dollars per incident. Labor rates at Mercedes-Benz dealerships or qualified independent specialists are also premium. Therefore, despite its low used purchase price, the 2006 S-Class is far from economical to own long-term, demanding a substantial ongoing financial commitment.

2006 Mercedes-Benz S-Class Fuel Efficiency

Fuel Type Gasoline
Fuel Capacity 51.77 liters
City Mileage 6.68 km/l
Highway Mileage 4.76 km/l

2006 Mercedes-Benz S-Class Safety Rating

NHTSA
Side Driver Rating
Frontal Passenger Rating
Rollover Rating
Side Rear Passenger Rating
Frontal Driver Rating
IIHS
Rear Crash Protection/Head Restraint Ratings Not Tested
Moderate Overlap Front Test Results Not Tested
Side Impact Test Results Not Tested

2006 Mercedes-Benz S-Class Warranty

Basic
Original warranty 48 months / 50,000 miles
Estimated remaining Expired
Powertrain
Original warranty 48 months / 50,000 miles
Estimated remaining Expired
Rust
Original warranty 48 months / 50,000 miles
Estimated remaining Expired

2006 Mercedes-Benz S-Class Insurance

Insurance for a 2006 Mercedes-Benz S-Class is moderately priced, reflecting its status as a Sedan with strong safety ratings and
reasonable repair costs.

How Does the 2006 Mercedes-Benz S-Class Compare to Other Sedan?

The 2006 Mercedes-Benz S-Class (W220) competed directly with rivals like the BMW 7 Series (E65/E66), Audi A8 (D3), Lexus LS 430, and Jaguar XJ (X350).

In performance, the S-Class offered a broad range from capable V8s to scorching AMG V12s, often leading its class in sheer power and smooth, refined acceleration. The BMW 7 Series offered a slightly sportier, more driver-focused handling dynamic, while the Audi A8 provided the advantage of standard Quattro all-wheel drive.

Regarding features, the S-Class was typically at the forefront, showcasing advanced tech like Distronic adaptive cruise control and the PRE-SAFE system. Its Airmatic suspension offered an unparalleled ride comfort. BMW's 7 Series introduced the revolutionary but often criticized iDrive interface, while the Audi A8 boasted a sophisticated aluminum space frame and an elegant interior. The Lexus LS 430 focused on understated luxury and exceptional refinement.

Reliability is where the S-Class often faces its toughest comparisons. While German engineering promised durability, the W220 S-Class, particularly with its complex Airmatic/ABC suspension and intricate electronics, gained a reputation for expensive and frequent repairs. The Lexus LS 430 is widely considered the gold standard for long-term reliability and lower ownership costs in this segment, though it lacked the raw power of the AMG S-Class. The BMW 7 Series and Audi A8 also had their share of electronic and mechanical complexities but sometimes fared slightly better than the W220 S-Class in certain areas, though all are costly to maintain.

In terms of used price, the S-Class depreciated heavily, making it a "bargain" buy initially compared to its original MSRP, often falling below some rivals due to its reputation for high running costs.

Alternatives:
  • For superior long-term reliability and lower running costs: The Lexus LS 430 (2001-2006) is an excellent choice, though less performance-oriented.
  • For a more modern experience with improved reliability: Consider the subsequent W221 generation Mercedes-Benz S-Class (2007-2013), which addressed many W220 issues and offered updated tech, albeit at a higher used price.
  • For a sportier luxury drive: A BMW 7 Series (E65/E66) can be an option, but be prepared for its own set of electrical and maintenance challenges.

Final Verdict: Is the 2006 Mercedes-Benz S-Class a Good Sedan?

The 2006 Mercedes-Benz S-Class is ideal for the automotive enthusiast or luxury car lover who deeply appreciates classic Mercedes engineering, comfort, and performance, and is fully prepared for significant long-term financial commitment. It's a fantastic choice for someone wanting immense luxury and presence for a bargain purchase price, provided they have a substantial budget for ongoing maintenance and repairs.

Is it worth buying? Yes, but only under very specific conditions. It must be purchased used, as new models are obviously no longer available. A pre-purchase inspection (PPI) by a Mercedes-Benz specialist is absolutely mandatory. Furthermore, prospective owners should factor in an annual "repair fund" of several thousand dollars. The S500 trim offers a good balance of features, power, and potentially less complexity than the V12 or AMG models. Avoid cars with vague service histories or obvious existing suspension issues. When well-maintained, it delivers an unparalleled luxury driving experience; when neglected, it becomes an expensive headache.

2006 Mercedes-Benz S-Class Owner Reviews

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Drew B

Drew is a seasoned automotive expert and contributor to VinCheck.info. With nearly 15 years of experience as a former Porsche technician, he brings a wealth of hands-on knowledge to his writing. Born in North Carolina, a region renowned for its deep-rooted NASCAR culture, Drew developed a passion for cars early in life, often building and working on vehicles from a young age. At VINCheck, Drew leverages his extensive technical background to provide in-depth analyses of various vehicles. His articles often focus on engine performance, reliability, and maintenance insights, offering readers practical information grounded in real-world experience. Some of his notable contributions include reviews on the Mazda CX-5's longevity and detailed examinations of engine options for models like the 2011 Toyota Camry and Tacoma