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2021 Mercedes-Benz S-Class Overview, Reviews, Ratings & Specs

Rating: 4.93
Based on 12 Owner Reviews â–¶
Eugene S | March 31, 2025
The Mercedes-Benz S-Class, a flagship luxury sedan, has long been synonymous with automotive excellence. The 2021 model year marks the start of a new generation (W223). Available as a four-door sedan, key trims include the S 500 and S 580. Pricing ranges from approximately $110,000 to well over $150,000 depending on options. It stands out for its cutting-edge technology, opulent interior, and smooth, powerful performance.
The Good

The 2021 S-Class excels in performance and comfort, providing a serene and powerful driving experience. The stunning design and luxurious interior appeal to emotional buyers, while the advanced safety tech and respectable fuel efficiency offer practical advantages. While not the cheapest, its prestigious image and technological advancements offer substantial value for discerning buyers.

The Bad

The 2021 S-Class, being a technologically advanced vehicle, can suffer from electronic gremlins and software glitches. High repair costs and expensive parts are a concern. Some owners have reported issues with the infotainment system and driver-assistance features. Complex systems might lead to long-term reliability concerns. Expect a higher depreciation rate than some rivals.

2021 Mercedes-Benz S-Class: Quick Overview

  • Engine Options:
    • S 500: 3.0-liter inline-6 turbo with mild hybrid system (EQ Boost)
    • S 580: 4.0-liter V8 biturbo with mild hybrid system (EQ Boost)
  • Horsepower:
    • S 500: 429 hp
    • S 580: 496 hp
  • Fuel Economy (EPA Estimated):
    • S 500: 21 mpg city / 30 mpg highway
    • S 580: 16 mpg city / 25 mpg highway
  • 0-60 mph Times:
    • S 500: Approximately 4.9 seconds
    • S 580: Approximately 4.4 seconds
  • Towing Capacity: Not designed for towing; negligible towing capacity.
  • Trim-Level Features:
    • Standard (both S 500 & S 580): 12.8-inch OLED touchscreen central display, 12.3-inch digital instrument cluster, MBUX infotainment system, Apple CarPlay, Android Auto, wireless charging, panoramic sunroof, leather upholstery, heated and ventilated front seats, active ambient lighting, advanced driver-assistance systems (adaptive cruise control, lane keeping assist, blind-spot monitoring), and more.
    • Optional Packages/Features: Executive Rear Seat Package (power-adjustable rear seats with massage function, rear-seat entertainment screens), augmented reality head-up display, Burmester 4D surround sound system, active steering assist, adaptive air suspension, and various interior trim options (wood, metal, carbon fiber). The S 580 also offers options like ceramic composite brakes.

2021 Mercedes-Benz S-Class Specifications

Vehicle Information
Year 2021
Make Mercedes-Benz
Model S-Class
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What Problems Does the 2021 Mercedes-Benz S-Class Have?

Being a relatively new model year, the 2021 S-Class hasn't accumulated a long history of widespread, documented issues compared to older vehicles. However, some common complaints and potential long-term reliability concerns have emerged. One major area is the MBUX infotainment system. Users have reported software glitches, slow response times, and occasional system freezes. The complex array of sensors and electronic components related to the driver-assistance features (adaptive cruise control, lane keeping assist) can also experience malfunctions.

Specific recalls for the 2021 model should be checked with the NHTSA (National Highway Traffic Safety Administration) database, as recalls can occur for various reasons, including safety-related defects. Given the S-Class's reliance on advanced technology, long-term reliability hinges on the durability of these electronic systems. Issues with the air suspension system are a possibility, as they can be costly to repair. Owners should also be mindful of the mild-hybrid system, as battery degradation over time could affect performance and fuel economy. Keeping up with scheduled maintenance and promptly addressing any warning lights or unusual behavior is critical for mitigating potential long-term problems. Early model years of a new generation often have more teething problems than later years, so prospective buyers should be aware of this.

How long will the 2021 Mercedes-Benz S-Class last?

With proper maintenance, a 2021 Mercedes-Benz S-Class can realistically provide 150,000 to 200,000 miles or 10-15 years of service. However, this is heavily dependent on meticulous maintenance. Long-term durability hinges on the electronic components and air suspension. Weaknesses typically emerge in the infotainment system, sensors, and the mild-hybrid battery. Neglecting maintenance can significantly shorten its lifespan and lead to expensive repairs. Regular servicing, using genuine Mercedes-Benz parts, and addressing issues promptly are crucial for maximizing longevity.

What Technology & Safety Features are Included?

The 2021 S-Class boasts an impressive array of technology. The centerpiece is the 12.8-inch OLED touchscreen central display running the MBUX infotainment system. It includes features like "Hey Mercedes" voice control, Apple CarPlay, and Android Auto. A 12.3-inch digital instrument cluster provides customizable information. Entertainment options include a premium Burmester surround sound system (optional 4D system available) and available rear-seat entertainment screens.

Driver-assistance features are abundant, including standard adaptive cruise control, lane keeping assist, blind-spot monitoring, automatic emergency braking, and a surround-view camera system. Optional features like active steering assist and augmented reality head-up display further enhance safety and convenience. Safety features include multiple airbags, electronic stability control, and anti-lock brakes.

As for crash-test ratings, the NHTSA (National Highway Traffic Safety Administration) and IIHS (Insurance Institute for Highway Safety) ratings should be consulted. The S-Class typically performs well in these tests, but specific 2021 ratings provide the most accurate information. Overall, the 2021 S-Class is a technology powerhouse with a strong emphasis on safety.

What Colors Options are Available?

Exterior Colors
Onyx Black
Obsidian Black Metallic
Graphite Grey Metallic
Rubellite Red Metallic
designo Diamond White Metallic
Emerald Green Metallic
Nautical Blue Metallic
Selenite Grey Metallic
Mojave Silver Metallic
designo Kalahari Gold Metallic
Interior Colors
Black Nappa Leather
Sienna Brown/Black Nappa Leather
Macchiato Beige/Magma Grey Nappa Leather
Black Exclusive Nappa Leather
Sienna Brown/Black Exclusive Nappa Leather
Macchiato Beige/Magma Grey Exclusive Nappa Leather
designo Crystal White/Silver Grey Exclusive Nappa Leather
AMG Black Nappa Leather
AMG Black Exclusive Nappa Leather
Silver Grey/Black Nappa Leather

2021 Mercedes-Benz S-Class Prices and Market Value

When new, the 2021 Mercedes-Benz S-Class started around $110,000 and could easily exceed $150,000 with options. Current used market prices vary significantly based on mileage, condition, and options, ranging from approximately $70,000 to $120,000+. The S-Class experiences significant depreciation in the first few years. Factors affecting resale value include mileage, condition, service history, original MSRP (due to options), and overall market demand for luxury sedans. Lower mileage and a clean Carfax report command higher prices.

2021 Mercedes-Benz S-Class Cost of Ownership

The 2021 Mercedes-Benz S-Class is costly to own. Insurance premiums are high due to the vehicle's value and repair costs. Fuel consumption is reasonable for its class, but still significant. Maintenance, especially at authorized dealerships, is expensive. Repairs, particularly for complex systems, can be substantial. Long-term ownership requires a dedicated budget for upkeep. It is far from economical and should be considered a luxury expense.

2021 Mercedes-Benz S-Class Fuel Efficiency

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2021 Mercedes-Benz S-Class Safety Rating

NHTSA
Overall Rating Not Tested
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Side Overall Star Rating Not Tested
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Frontal Barrier Star Ratings Not Tested
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Combined Side Barrier And Side Pole Star Ratings Not Tested
Rollover Resistance Star Rating Not Tested

2021 Mercedes-Benz S-Class Insurance

Insurance for a 2021 Mercedes-Benz S-Class is moderately priced, reflecting its status as a Vehicle with strong safety ratings and
reasonable repair costs.

How Does the 2021 Mercedes-Benz S-Class Compare to Other Vehicle?

The 2021 Mercedes-Benz S-Class competes with the BMW 7 Series, Audi A8, Lexus LS, and Porsche Panamera. In terms of performance, the S-Class is generally comparable, with the Panamera offering a sportier driving experience. Features are a strong point for the S-Class, boasting cutting-edge technology. However, reliability is where the S-Class can lag behind the Lexus LS, known for its dependability. Price-wise, the S-Class is competitive within its segment.

Alternatives to consider: The BMW 7 Series offers a similar blend of luxury and performance, with a slightly more driver-focused experience. The Audi A8 provides a technologically advanced and stylish option. The Lexus LS excels in reliability and comfort. The Porsche Panamera caters to those seeking a sportier driving experience with luxury amenities. Whether an alternative is "better" depends on individual priorities. If reliability is paramount, the Lexus LS is a strong contender. For a more engaging driving experience, the Porsche Panamera stands out.

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6 2024 BMW M3 (0.0★)
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10 2023 Chevrolet Camaro (5.0★)
11 2023 Hyundai Elantra Hybrid (0.0★)
12 2023 Nissan Altima (4.0★)
523 2021 Mercedes-Benz S-Class (5.0★)

Final Verdict: Is the 2021 Mercedes-Benz S-Class a Good Vehicle?

The 2021 Mercedes-Benz S-Class is ideal for buyers who prioritize luxury, technology, and a comfortable driving experience above all else. It's worth buying if you appreciate the latest innovations and are prepared for potentially high ownership costs. A used model can offer significant savings, but a thorough inspection is crucial to assess its condition and maintenance history. Lower trims like the S 500 provide excellent value, while the S 580 offers more power. It's best to purchase from a reputable dealer with a comprehensive warranty to mitigate potential repair costs.

2021 Mercedes-Benz S-Class Owner Reviews

4.93
Consumer Rating, Based on 12 Consumer Reviews
Overall rating
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Beverly on April 21, 2024

Love my Mercedes

I have been driving Mercedes Benz s class vehicles for over 10 years, traded every 3-4 years and have been very happy, always have them serviced at the dealer, always received a loaner, no complaints.

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Jeffery Williams on November 1, 2023

An Absolute Dream

I have owned 6 S Class (SonderKlas) cars in my life and each and every single one has been problem free and a pure joy to own, drive, and admire. The 2021 S580 however.. Well this car is truly something special and not an incremental upgrade! This thing is crazy

Was this review helpful?
1
0

Tarek M on April 21, 2023

Luxury

Luxury at its best, you can’t get better than that with this price range. S 580 is the way to go, the 8 cylinders are so smooth yet so sporty. This car can be Rolls Royce luxury and lamborghini urus if it wants

Was this review helpful?
1
0

Beverly on April 21, 2024

Love my Mercedes

I have been driving Mercedes Benz s class vehicles for over 10 years, traded every 3-4 years and have been very happy, always have them serviced at the dealer, always received a loaner, no complaints.

Was this review helpful?
1
0

Jeffery Williams on November 1, 2023

An Absolute Dream

I have owned 6 S Class (SonderKlas) cars in my life and each and every single one has been problem free and a pure joy to own, drive, and admire. The 2021 S580 however.. Well this car is truly something special and not an incremental upgrade! This thing is crazy

Was this review helpful?
1
0

Tarek M on April 21, 2023

Luxury

Luxury at its best, you can’t get better than that with this price range. S 580 is the way to go, the 8 cylinders are so smooth yet so sporty. This car can be Rolls Royce luxury and lamborghini urus if it wants

Was this review helpful?
1
0

Beverly on April 21, 2024

Love my Mercedes

I have been driving Mercedes Benz s class vehicles for over 10 years, traded every 3-4 years and have been very happy, always have them serviced at the dealer, always received a loaner, no complaints.

Was this review helpful?
1
0

Jeffery Williams on November 1, 2023

An Absolute Dream

I have owned 6 S Class (SonderKlas) cars in my life and each and every single one has been problem free and a pure joy to own, drive, and admire. The 2021 S580 however.. Well this car is truly something special and not an incremental upgrade! This thing is crazy

Was this review helpful?
1
0

Tarek M on April 21, 2023

Luxury

Luxury at its best, you can’t get better than that with this price range. S 580 is the way to go, the 8 cylinders are so smooth yet so sporty. This car can be Rolls Royce luxury and lamborghini urus if it wants

Was this review helpful?
1
0

Beverly on April 21, 2024

Love my Mercedes

I have been driving Mercedes Benz s class vehicles for over 10 years, traded every 3-4 years and have been very happy, always have them serviced at the dealer, always received a loaner, no complaints.

Was this review helpful?
1
0
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Eugene S

Eugene is an automotive enthusiast with over 15 years of experience in the used car market. As a writer at VINCheck.info, he brings deep industry insight and a passion for cars, helping readers make smart, informed decisions. Eugene has written hundreds of used car reviews and is known for breaking down complex automotive topics into clear, actionable advice. Over the years, he has driven and worked on a wide range of vehicles—starting with tuning street cars in his early days and eventually focusing on performance upgrades and reliability improvements. Today, he specializes in evaluating used vehicles through the lens of real-world ownership and enthusiast needs. A longtime fan of Porsche, Eugene especially appreciates vehicles that blend durability with driving enjoyment.