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2006 Mercedes-Benz E-Class Overview, Reviews, Ratings & Specs

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Cathleen V | September 24, 2025
The 2006 Mercedes-Benz E-Class, part of the W211 generation (2003-2009), offered a blend of luxury and performance. Available as a sedan and wagon, its key trims included the E320, E350, E500, and the high-performance E55 AMG. Original pricing ranged from around $48,000 to over $80,000 for the AMG. It stood out for its elegant design, advanced technology, and comfortable ride, making it a popular choice among luxury car buyers.
The Good

The 2006 E-Class delivers a comfortable and refined ride, appealing to those seeking luxury and status. Its powerful engine options and responsive handling satisfy performance enthusiasts. While not known for stellar reliability, its solid build quality and elegant design offer enduring value. Practical buyers appreciate its spacious interior and advanced safety features.

The Bad

The 2006 E-Class is known for potential issues with its Airmatic suspension system, which can be costly to repair. Electrical glitches, including issues with the COMAND system and sensors, are also common. Oil leaks, particularly from the valve cover gaskets, should be inspected. Regular maintenance is crucial to prevent major problems.

2006 Mercedes-Benz E-Class: Quick Overview

  • Engine Options:
    • E320: 3.2L V6 (221 hp)
    • E350: 3.5L V6 (268 hp)
    • E500: 5.0L V8 (302 hp)
    • E55 AMG: 5.5L Supercharged V8 (469 hp)
  • Horsepower: Ranges from 221 hp to 469 hp, depending on the engine.
  • Fuel Economy:
    • E320: Around 18 mpg city / 26 mpg highway
    • E350: Around 18 mpg city / 25 mpg highway
    • E500: Around 16 mpg city / 23 mpg highway
    • E55 AMG: Around 14 mpg city / 20 mpg highway
  • 0-60 Times:
    • E320: Around 7.5 seconds
    • E350: Around 6.7 seconds
    • E500: Around 6.1 seconds
    • E55 AMG: Around 4.6 seconds
  • Towing Capacity: Not typically advertised for the E-Class, but generally not recommended for significant towing.
  • Trim-Level Features:
    • E320/E350: Leather upholstery, power front seats, dual-zone automatic climate control, sunroof, premium sound system, and stability control.
    • E500: Adds features like Airmatic suspension, upgraded leather, and more luxurious interior trim.
    • E55 AMG: High-performance brakes, AMG-tuned suspension, aggressive body styling, sport seats, and unique interior accents. All E-Class models also included safety features such as antilock brakes (ABS), traction control, and multiple airbags. Optional features across the range included navigation, upgraded sound systems, heated seats, and keyless entry.

2006 Mercedes-Benz E-Class Specifications

Vehicle Information
Year 2006
Make Mercedes-Benz
Model E-Class
Trim -
Style 4-Door Sedan 3.5-Liter
Type Sedan
Category Mid-Size Car
Manufacturing Details
Made In Germany
Manufacturing City SINDELFINGEN
Dimensions
Doors 4-Door
Curb Weight -
Gross Vehicle Weight Rating -
Overall Height -
Overall Length -
Overall Width -
Wheelbase Length -
Standard Seating 7
Engine & Performance
Engine 3.5 6
Engine Size 3.5L
Engine Cylinders 6
Transmission 5-Speed Automatic
Transmission Type Automatic
Transmission Speeds 5-Speed
Drivetrain All-Wheel Drive
Additional Features
Anti-Brake System -
Steering Type -
Pricing
Manufacturer Suggested Retail Price (MSRP) $52,550 USD
Invoice Price $48,872 USD
Delivery Charges $775 USD

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Analysis

What Problems Does the 2006 Mercedes-Benz E-Class Have?

The 2006 Mercedes-Benz E-Class, while luxurious, has several frequently reported problems. The Airmatic suspension system is a common source of issues, with air struts and compressors failing, leading to costly repairs. Electrical problems are also prevalent, including malfunctioning sensors, issues with the COMAND system (navigation and entertainment), and problems with the instrument cluster. Oil leaks, particularly from the valve cover gaskets and oil cooler lines, are another concern.

Recalls for the 2006 E-Class have addressed issues such as fuel filter leaks, potential brake line corrosion (in specific regions), and issues with the supplemental restraint system (airbags). Long-term reliability can be a concern due to the complexity of the vehicle's systems. Owners often report higher maintenance costs compared to some competitors.

Specifically, 2006 models (and those around it) may exhibit premature wear of the front suspension components, particularly ball joints and control arm bushings. Regular inspection and timely replacement of worn parts are essential to prevent further damage and maintain safe handling. Addressing these issues proactively is crucial for a positive ownership experience.

How long will the 2006 Mercedes-Benz E-Class last?

With proper maintenance, a 2006 Mercedes-Benz E-Class can easily reach 200,000 miles or more and provide 15-20 years of service. However, longevity heavily depends on maintenance habits. Neglecting scheduled servicing, especially oil changes and fluid flushes, drastically reduces lifespan. Long-term durability weaknesses include the aforementioned Airmatic suspension failures, electrical gremlins that accumulate with age, and potential rust issues in colder climates. Models with consistent and meticulous maintenance records generally fare much better, demonstrating greater resilience over time.

What Technology & Safety Features are Included?

The 2006 Mercedes-Benz E-Class boasts a comprehensive suite of technology and safety features for its time. Standard features include the COMAND system (central control for audio, navigation, and vehicle settings), dual-zone automatic climate control, a premium sound system, and power-adjustable front seats. Driver-assistance features were relatively limited compared to modern cars but included cruise control and rain-sensing wipers.

Safety features were a strong point, with standard antilock brakes (ABS), traction control, stability control, and multiple airbags (front, side, and curtain). Optional features included Parktronic (parking sensors) and bi-xenon headlights.

Optional tech and entertainment upgrades included a navigation system, a Harman Kardon Logic7 surround-sound system, and heated front seats. The COMAND system, while advanced for its time, can feel dated by modern standards. Crash-test ratings from the IIHS (Insurance Institute for Highway Safety) were generally good for the 2006 E-Class, earning "Good" ratings in most categories. NHTSA (National Highway Traffic Safety Administration) ratings varied by test, but overall, the E-Class provided a solid level of safety for its era. The advanced airbags and robust structure were key contributors to its safety performance.

What Colors Options are Available?

Exterior Colors
Black
Arctic White
Mars Red
Pewter Metallic
Flint Grey Metallic
Capri Blue Metallic
Jade Green Metallic
Desert Sand Metallic
Alabaster White
Black Opal Metallic
Quartz Blue Metallic
Interior Colors
Cognac Brown
Black
Grey
Orion Blue

2006 Mercedes-Benz E-Class Prices and Market Value

When new, the 2006 Mercedes-Benz E-Class ranged from approximately $48,000 for the E320 to over $80,000 for the E55 AMG. Currently, used market prices vary significantly based on condition, mileage, and trim level. Expect to find examples ranging from $5,000 to $15,000. Depreciation has been substantial, typical for luxury cars. Factors affecting resale value include a clean title, documented service history, low mileage, and desirable options. The AMG models generally hold their value better due to their performance and rarity.

2006 Mercedes-Benz E-Class Cost of Ownership

Owning a 2006 Mercedes-Benz E-Class is generally considered costly. Insurance premiums are higher than average. Fuel costs are moderate, depending on the engine, but repairs and maintenance can be expensive. Parts, especially for the Airmatic suspension and electrical systems, are pricey, and labor costs at qualified Mercedes-Benz mechanics are also significant. Long-term ownership requires a dedicated budget for upkeep and preventative maintenance to avoid major breakdowns.

2006 Mercedes-Benz E-Class Fuel Efficiency

Fuel Type Gasoline (Required)
Fuel Capacity 77.98 liters
City Mileage 6.8 km/l
Highway Mileage 9.78 km/l

2006 Mercedes-Benz E-Class Safety Rating

NHTSA
Side Driver Rating
Frontal Passenger Rating
Rollover Rating
Side Rear Passenger Rating
Frontal Driver Rating
IIHS
Rear Crash Protection/Head Restraint Ratings Good
Moderate Overlap Front Test Results Good
Side Impact Test Results Not Tested

2006 Mercedes-Benz E-Class Insurance

Insurance for a 2006 Mercedes-Benz E-Class is moderately priced, reflecting its status as a Sedan with strong safety ratings and
reasonable repair costs.

How Does the 2006 Mercedes-Benz E-Class Compare to Other Sedan?

The 2006 Mercedes-Benz E-Class competed with the BMW 5 Series (E60), Audi A6 (C6), and Lexus GS. In terms of performance, the E55 AMG outshone most rivals, while the other E-Class models offered competitive power. Features were generally comparable across the class, although the E-Class often boasted a more luxurious interior. However, reliability is where the E-Class often lagged. The BMW 5 Series and Lexus GS were generally considered more reliable options.

In terms of price, the E-Class was typically in line with its German competitors but more expensive than the Lexus GS. If reliability is a top priority, the Lexus GS 300/350 or the Acura TL (though smaller) are better alternatives. The BMW 5 Series offers a similar driving experience but with potentially higher maintenance costs as well. The Audi A6 provides a blend of luxury and performance but shares some of the E-Class's potential reliability concerns. Ultimately, the best alternative depends on individual priorities, with the Lexus GS standing out for reliability and the BMW 5 Series for a sportier driving experience.

Final Verdict: Is the 2006 Mercedes-Benz E-Class a Good Sedan?

The 2006 Mercedes-Benz E-Class is ideal for someone who appreciates luxury, style, and a comfortable ride, and is prepared to invest in maintenance. It's worth buying used *if* you find a well-maintained example with a comprehensive service history and pre-purchase inspection by a qualified mechanic. Avoid models with a history of Airmatic suspension problems or electrical issues. Lower trim levels (E320 or E350) may be more reliable than the E500 or E55 AMG. For enthusiasts seeking performance, the E55 AMG is tempting, but be prepared for potentially higher running costs. Overall, proceed with caution and prioritize condition over price.

2006 Mercedes-Benz E-Class Owner Reviews

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Cathleen V

Cathleen is an exceptional freelance writer covering hot topics in the automotive world from a gearhead's perspective. Her articles delve into various aspects of automotive technology and history, offering readers detailed insights into engine performance, reliability, and maintenance. Through her engaging and informative writing, Cathleen provides valuable information to automotive enthusiasts and consumers alike, helping them make informed decisions about vehicle maintenance and purchases.