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2021 Ram 4500 Overview, Reviews, Ratings & Specs

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Eugene S | March 31, 2025
The 2021 Ram 4500 is a heavy-duty chassis cab truck designed for commercial use, tracing its roots back to the robust Dodge Ram platform. It's available exclusively as a chassis cab, ready to be upfitted for various applications. Key trims focus on capability rather than luxury. Pricing typically ranges from $45,000 to $65,000+, depending on configuration and upfitting. It's popular due to its immense towing capacity and powerful engine options, making it a workhorse for businesses.
The Good

The 2021 Ram 4500 offers exceptional performance and towing power, crucial for practical buyers. While not focused on luxury, it provides a comfortable and functional interior. Its robust design inspires confidence, and its proven powertrain suggests reliability, appealing to those seeking a dependable work truck. Value lies in its capability and durability.

The Bad

The 2021 Ram 4500, being a heavy-duty work truck, prioritizes function over fuel efficiency. Expect higher running costs. The ride can be stiff when unladen. Potential buyers should also watch for issues related to the upfit, as these are often not covered by the factory warranty. Overall, reliability concerns related to emissions equipment can occur.

2021 Ram 4500: Quick Overview

  • Engine Options: 6.4L HEMI V8 gasoline engine, 6.7L Cummins Turbo Diesel I6
  • Horsepower: 6.4L HEMI V8: 410 hp, 6.7L Cummins Turbo Diesel I6: 360 hp
  • Fuel Economy: Fuel economy is not officially rated for chassis cab trucks, but expect significantly lower mpg than consumer trucks, especially with the diesel. Expect single digit MPG when towing.
  • 0-60 Times: 0-60 times are not typically published for chassis cab trucks. Acceleration is geared towards hauling and towing, not speed.
  • Towing Capacity: Towing capacity can vary greatly depending on the upfit and configuration, but can exceed 30,000 lbs with the diesel engine.
  • Trim-Level Features:
    • Tradesman: Basic work truck, vinyl seats, steel wheels, minimal infotainment features.
    • SLT: Adds cloth seats, chrome exterior trim, and some upgraded infotainment options.
    • Higher trims may be available through upfitters, adding features like leather seats, navigation, and advanced safety systems.
  • Other Key Specs:
    • Rear-wheel drive is standard, with four-wheel drive available.
    • Axle ratios are customizable for specific hauling needs.
    • GVWR (Gross Vehicle Weight Rating) is a key consideration for commercial applications.
    • Braking system designed for heavy loads.
  • The primary focus is on capability and durability. Interior features are secondary to functionality. Upfitting options significantly impact the final specification and purpose of the vehicle.

2021 Ram 4500 Specifications

Vehicle Information
Year 2021
Make Ram
Model 4500
Trim -
Style SWB Regular Cab 2WD
Type Pickup Truck
Category Heavy Truck
Manufacturing Details
Made In Mexico
Manufacturing City SALTILLO
Dimensions
Doors 4-Door
Curb Weight -
Gross Vehicle Weight Rating 16000 pounds
Overall Height -
Overall Length -
Overall Width -
Wheelbase Length swb
Standard Seating -
Engine & Performance
Engine 6.7-L L-6 OHV 24V Turbo Diesel
Engine Size 6.7L
Engine Cylinders 6
Transmission 6-Speed
Transmission Type -
Transmission Speeds 6-Speed
Drivetrain Rear-Wheel Drive
Additional Features
Anti-Brake System -
Steering Type -
Pricing
Manufacturer Suggested Retail Price (MSRP) -
Invoice Price -
Delivery Charges -

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What Problems Does the 2021 Ram 4500 Have?

Frequently reported problems for the 2021 Ram 4500 often relate to the complex emissions systems on the diesel engine, including issues with the diesel particulate filter (DPF), diesel exhaust fluid (DEF) systems, and related sensors. These can trigger warning lights and potentially lead to reduced engine performance. Some owners have reported electrical gremlins, particularly in the infotainment system or related to the chassis wiring. Recalls can occur, and it's essential to check the NHTSA website for any outstanding recalls related to the specific VIN. Long-term reliability concerns primarily revolve around the durability of the heavy-duty components under sustained heavy use. This includes the transmission, axles, and suspension. Preventative maintenance, especially frequent fluid changes and inspections, is crucial for maximizing longevity. Some users have cited instances of premature wear on ball joints and other front-end components, particularly when the truck is regularly operated at or near its maximum GVWR. The 2021 model year doesn't have dramatically different common issues than other similar model years of the Ram 4500, but staying up-to-date on TSBs (Technical Service Bulletins) is advisable.

How long will the 2021 Ram 4500 last?

The 2021 Ram 4500, when properly maintained, is designed for a long service life. Many commercial users aim for 200,000 - 300,000 miles or 10-15 years of service. However, mileage and longevity are highly dependent on maintenance habits and usage. Regular oil changes, fluid flushes, and inspections are crucial. Weaknesses over time often involve wear and tear on suspension components, brake systems, and the emissions systems of the diesel engine. Neglecting maintenance can significantly shorten its lifespan and lead to costly repairs. Rust can also be a concern in regions with harsh winters.

What Technology & Safety Features are Included?

The 2021 Ram 4500 prioritizes functionality over advanced technology. The base Tradesman trim offers minimal tech. Higher trims like the SLT offer options such as a Uconnect infotainment system with a touchscreen display (typically 5-inch or 8.4-inch), Bluetooth connectivity, and smartphone integration (Apple CarPlay and Android Auto). Built-in navigation may be optional. Driver-assistance features are generally limited to basic features like electronic stability control (ESC) and traction control. Optional features may include a rearview camera, particularly important for a vehicle of this size. Blind-spot monitoring and rear cross-path detection might be available as part of specific packages or upfits, but are not standard. Crash-test ratings from agencies like NHTSA and IIHS are typically *not* conducted for chassis cab trucks because they are designed to be completed by second-stage manufacturers. Safety features include standard airbags (front and side), anti-lock brakes (ABS), and seatbelts. The focus is on providing a safe and reliable platform for commercial use, rather than offering cutting-edge technology.

What Colors Options are Available?

Exterior Colors
Bright White Clearcoat
Delmonico Red Pearlcoat
Granite Crystal Metallic Clearcoat
Maximum Steel Metallic Clearcoat
Patriot Blue Pearlcoat
Diamond Black Crystal Pearlcoat
Walnut Brown Metallic Clearcoat
RV Match Walnut Brown
Case IH Red
New Holland Blue
Black
Interior Colors
Light Mountain Brown/Cattle Tan
Black/Diesel Gray

2021 Ram 4500 Prices and Market Value

When new, the 2021 Ram 4500 typically ranged from $45,000 to $65,000+, depending on the trim and options. Used market prices vary widely based on mileage, condition, and any upfitting modifications. Expect to find used models ranging from $35,000 to $55,000 or more. Depreciation is generally less steep than on consumer trucks, as demand for reliable work trucks remains strong. Factors affecting resale value include engine type (diesel models hold their value better), mileage, condition, and any included upfitting (e.g., flatbed, crane). Well-maintained trucks with desirable upfits command higher prices.

2021 Ram 4500 Cost of Ownership

The 2021 Ram 4500 is not an economical vehicle to own. Insurance costs are typically higher due to its commercial nature and higher replacement value. Fuel costs, especially for diesel models under heavy load, are substantial. Maintenance, including oil changes and tire replacements, is more frequent and expensive than for passenger vehicles. Repairs can also be costly, particularly for the diesel engine and associated components. Long-term ownership costs should be carefully considered before purchasing.

2021 Ram 4500 Fuel Efficiency

Fuel Type Diesel
Fuel Capacity -
City Mileage -
Highway Mileage -

2021 Ram 4500 Recalls & Defects

Electrical System:wiring:relays/Solenoids
Recall date 2021-10-14
Recall no. 21v798000
Source NHTSA
Summary Chrysler (Fca US, Llc) IS Recalling Certain 2021-2022 RAM 3500, 2500 Pickup Trucks, and RAM 3500, 4500, and 5500 Cab Chassis Vehicles Equipped With Cummins 6.7l Turbo Diesel Engines. AN Electrical Short IN THE Relay MAY Cause A Vehicle Fire With THE Ignition ON or Off.
Consequence A Vehicle Fire Increases THE Risk OF Injury.
Remedy Owners ARE Advised TO Park These Vehicles Outside OF Buildings or Structures, and NOT Near Other Vehicles, Until THE Vehicle HAS Been Remedied. Dealers Will Inspect And, IF Needed, Replace THE Solid State Intake Heater Grid Relay ("relay"); IF FCA US Recall ID Y08 (Nhtsa Recall ID 21v-163) IS Open, Then Insulating Material Will BE Applied TO THE Relay After Inspection. Owner Notification Letters Were Mailed November 10, 2021. Owners MAY Contact FCA US, LLC Customer Service AT 1-800-853-1403. FCA US, Llc's Number FOR This Recall IS Y76. This Recall HAS Been Superseded BY 23v060.
Notes Owners MAY Also Contact THE National Highway Traffic Safety Administration Vehicle Safety Hotline AT 1-888-327-4236 (Tty 1-800-424-9153), or GO TO Www.nhtsa.gov.
Wheels:lugs/Nuts/Bolts/studs
Recall date 2021-05-27
Recall no. 21v398000
Source NHTSA
Summary Chrysler (Fca US, Llc) IS Recalling Certain 2012-2021 RAM 3500, 3500 Cab Chassis, 4500 Cab Chassis, and 5500 Cab Chassis Vehicles. Incorrect Information IN THE Service and Owner's Manuals MAY Cause THE Flanged LUG Nuts TO BE Over-Tightened, Which Could Result IN A Broken Wheel Stud and Possible Wheel Separation.
Consequence Wheel Separation CAN Cause A Vehicle Crash.
Remedy Dealers Will Update THE Torque Specification IN THE Owner's Manual and Other Published Service Documents. Dealers Will Also Inspect THE Vehicle's Wheel Studs, Replacing Them IF Necessary, Free OF Charge. Owner Notification Letters Were Mailed ON November 30, 2021. Campaign Y36 Owner Notification Letters Were Mailed ON November 30, 2021. Campaign Y26 Owner Notification Letters Were Mailed ON December 1, 2021. Owners MAY Contact FCA US Customer Service AT 1-800-853-1403. FCA Us's Numbers FOR This Recall ARE Y26 and Y36.
Notes Owners MAY Also Contact THE National Highway Traffic Safety Administration Vehicle Safety Hotline AT 1-888-327-4236 (Tty 1-800-424-9153), or GO TO Www.nhtsa.gov.
Electrical System
Recall date 2021-03-11
Recall no. 21v163000
Source NHTSA
Summary Chrysler (Fca US, Llc) IS Recalling Certain 2021 RAM 2500, 3500, and 3500, 4500, and 5500 Cab Chassis Vehicles Equipped With A Cummins 6.7l Turbo Diesel Engine. AN Electrical Short MAY Occur IN THE Solid State Intake Heater Grid Relay, Which Could Result IN A Vehicle Fire.
Consequence A Vehicle Fire Increases THE Risk OF Injury.
Remedy Dealers Will Inspect And, IF Needed, Replace THE Solid State Intake Heater Grid Relay ("relay"); IF FCA US Recall ID Y08 (Nhtsa Recall ID 21v-163) IS Open, Then Insulating Material Will BE Applied TO THE Relay After Inspection. Customers ARE Advised TO NOT Park These Vehicles Inside OF Buildings or Structures, or Near Other Vehicles Until THE Vehicle HAS THE Final Repair Completed. Owner Notification Letters Were Mailed November 10, 2021. Owners MAY Contact FCA US, LLC Customer Service AT 1-800-853-1403. FCA US, Llc's Number FOR This Recall IS Y76. Owners MAY Contact FCA US LLC Customer Service AT 1-800-853-1403. FCA US Llc's Number FOR This Recall IS Y08. This Recall HAS Been Superseded BY Recall Number 21v-798.
Notes Owners MAY Also Contact THE National Highway Traffic Safety Administration Vehicle Safety Hotline AT 1-888-327-4236 (Tty 1-800-424-9153), or GO TO Www.safercar.gov.
Electrical System:wiring:relays/Solenoids
Recall date 2023-02-09
Recall no. 23v060000
Source NHTSA
Summary Chrysler (Fca US, Llc) IS Recalling Certain 2021-2023 RAM 2500, 3500, 3500 Cab Chassis, and 4500, 5500 Cab Chassis Vehicles Equipped With A Cummins 6.7l Turbo Diesel Engine. AN Electrical Short MAY Occur IN THE Heater Grid Relay With THE Ignition ON or Off.
Consequence AN Electrical Short IN THE Relay CAN Result IN AN Engine Compartment Fire With THE Ignition ON or Off, Increasing THE Risk OF Injury.
Remedy Owners ARE Advised TO Park Outside and Away From Structures Until THE Recall Repair IS Complete. Dealers Will Replace THE Relay, Free OF Charge. This Will BE A Phased Campaign. Phase 1 Will Include 2023 Model Year Vehicles. FCA US Will Notify Dealers ON or About 3/23/2023 and Begin Notifying Owners ON or About 4/5/2023. Phase 2 Will Include 2022 Model Year Vehicles and Phase 3 Will Include 2021 Model Year Vehicles. FCA US Will Notify Dealers and Owners ON or About 4/27/2023 FOR Phase 2 and 5/11/2023 FOR Phase 3. Interim Owner Notification Letters Informing Owners OF THE Safety Risk Were Mailed March 28, 2023. Owner Notification Letters ARE Expected TO BE Mailed April 5, 2023. Owners MAY Contact FCA US, LLC Customer Service AT 1-800-853-1403. FCA US, Llc's Number FOR This Recall IS 13a. This Recall IS AN Expansion OF and Supersedes Recall Number 21v-798.
Notes Owners MAY Also Contact THE National Highway Traffic Safety Administration Vehicle Safety Hotline AT 1-888-327-4236 (Tty 1-800-424-9153), or GO TO Www.nhtsa.gov.

2021 Ram 4500 Warranty

Basic
Original warranty 0 months / No data
Estimated remaining Expired
Powertrain
Original warranty 0 months / No data
Estimated remaining Expired
Rust
Original warranty 0 months / No data
Estimated remaining Expired

2021 Ram 4500 Insurance

Insurance for a 2021 Ram 4500 is moderately priced, reflecting its status as a Pickup Truck with strong safety ratings and
reasonable repair costs.

How Does the 2021 Ram 4500 Compare to Other Pickup Truck?

The 2021 Ram 4500 competes with the Ford F-450 and the Chevrolet Silverado 4500HD/GMC Sierra 4500HD in the heavy-duty chassis cab segment. In terms of performance, all three offer comparable towing and hauling capabilities, with diesel engine options providing a significant advantage. The Ram often receives praise for its ride quality compared to Ford, though this is less of a factor for work trucks. Features are generally similar across the brands, with base trims offering minimal amenities and higher trims providing more comfort and tech options. Reliability is a key consideration, and all three brands have their share of potential issues, particularly with emissions systems on diesel models. Price points are also relatively similar. Ultimately, the "best" choice depends on specific needs and preferences. Some users might prefer the Ford's proven track record, while others appreciate the Ram's interior design. The Chevrolet/GMC twins offer a similar experience. There isn't a clearly "better" alternative; it's more about finding the specific configuration and upfit that best suits the intended application and budget. Considering Isuzu commercial trucks can be an option where ultimate durability and different cab-over designs are needed.

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Final Verdict: Is the 2021 Ram 4500 a Good Pickup Truck?

The 2021 Ram 4500 is ideal for businesses and individuals requiring a heavy-duty chassis cab truck for demanding commercial applications. It's worth buying if you need its immense towing capacity and are prepared for the higher operating costs. A used model can be a good value, but thoroughly inspect it for maintenance records and potential issues. Consider the diesel engine if heavy towing is a regular requirement. The Tradesman trim is suitable for basic work needs, while the SLT offers a few more comfort features. Ensure the upfit meets your specific requirements before purchasing. Prioritize a well-maintained vehicle with a clear history.

2021 Ram 4500 Owner Reviews

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Eugene S

Eugene is an automotive enthusiast with over 15 years of experience in the used car market. As a writer at VINCheck.info, he brings deep industry insight and a passion for cars, helping readers make smart, informed decisions. Eugene has written hundreds of used car reviews and is known for breaking down complex automotive topics into clear, actionable advice. Over the years, he has driven and worked on a wide range of vehiclesβ€”starting with tuning street cars in his early days and eventually focusing on performance upgrades and reliability improvements. Today, he specializes in evaluating used vehicles through the lens of real-world ownership and enthusiast needs. A longtime fan of Porsche, Eugene especially appreciates vehicles that blend durability with driving enjoyment.